Sparfloxacin. A review of its antibacterial activity, pharmacokinetic properties, clinical efficacy and tolerability in lower respiratory tract infections (Q28307380)

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English	Sparfloxacin. A review of its antibacterial activity, pharmacokinetic properties, clinical efficacy and tolerability in lower respiratory tract infections	scientific article

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scholarly article

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Europe PubMed Central

Sparfloxacin. A review of its antibacterial activity, pharmacokinetic properties, clinical efficacy and tolerability in lower respiratory tract infections (English)

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pharmacokinetics

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based on heuristic

inferred from title

Alexander Markham

3

object named as

A Markham

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author name string

K L Goa

1

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H M Bryson

2

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A Markham

3

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language of work or name

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publication date

April 1997

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53

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4

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700-25

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Management of community acquired lower respiratory tract infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overview of electrocardiographic and cardiovascular safety data for sparfloxacin. Sparfloxacin Safety Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minimizing the impact of drug-resistant Streptococcus pneumoniae (DRSP). A strategy from the DRSP Working Group

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https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Torsades de pointe probably related to sparfloxacin

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https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple-dose pharmacokinetics of sparfloxacin and its influence on fecal flora

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of sparfloxacin in healthy volunteers and patients: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of sparfloxacin and serum bactericidal activity against pneumococci

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

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Pharmacokinetic drug interactions of macrolides

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https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

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Bactericidal Kinetics and Postantibiotic Effect of Sparfloxacin against Selected Species of Respiratory Pathogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

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Effect of Sparfloxacin on Fecal Microflora and its Fecal Concentration in Patients with Bacillary Dysentery

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A review of the penetration of sparfloxacin into the lower respiratory tract and sinuses

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative in vitro activities of sparfloxacin (CI-978; AT-4140) and other antimicrobial agents against staphylococci, enterococci, and respiratory tract pathogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo efficacy of a new fluoroquinolone, sparfloxacin, against penicillin-susceptible and -resistant and multiresistant strains of Streptococcus pneumoniae in a mouse model of pneumonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in adherence of respiratory pathogens to HEp-2 cells induced by subinhibitory concentrations of sparfloxacin, ciprofloxacin, and trimethoprim

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition by quinolones of DNA gyrase from Staphylococcus aureus

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postantibiotic effect, and postantibiotic effect of subinhibitory concentrations, of sparfloxacin on gram-negative bacteria.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro activities of sparfloxacin, tosufloxacin, ciprofloxacin, and fleroxacin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In-vitro activity of sparfloxacin, a new quinolone antimicrobial agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sparfloxacin worldwide in vitro literature: isolate data available through 1994.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of antacid on absorption and excretion of new quinolones

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

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Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pneumonia in the elderly

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multicenter evaluation of the in vitro activities of three new quinolones, sparfloxacin, CI-960, and PD 131,628, compared with the activity of ciprofloxacin against 5,252 clinical bacterial isolates

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antistaphylococcal activities of sparfloxacin (CI-978; AT-4140), ofloxacin, and ciprofloxacin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[In vitro activity of sparfloxacin against methicillin-resistant staphylococci].

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo activities of sparfloxacin against Mycoplasma pneumoniae

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationships among antibacterial activity, inhibition of DNA gyrase, and intracellular accumulation of 11 fluoroquinolones

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of resistance to quinolones

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro activity of sparfloxacin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

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Sparfloxacin secretion across Caco-2 cells involves a multidrug resistance-like mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro activity of sparfloxacin and three other fluoroquinolones against methicillin-resistantStaphylococcus aureus andStaphylococcus epidermidis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tolerability of fluoroquinolone antibiotics. Past, present and future

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of sparfloxacin in patients with renal impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro antimicrobial activity of sparfloxacin (AT-4140, CI-978, PD 131501) compared with numerous other quinolone compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of sparfloxacin in humans after single oral administration at doses of 200, 400, 600, and 800 mg

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced susceptibilities of Shigella sonnei strains isolated from patients with dysentery to fluoroquinolones

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro activity of sparfloxacin (CI-978; AT-4140) for clinical Legionella isolates, pharmacokinetics in guinea pigs, and use to treat guinea pigs with L. pneumophila pneumonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of action of sparfloxacin against and mechanism of resistance in gram-negative and gram-positive bacteria

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sparfloxacin, a new generation fluoroquinolone against S. pneumoniae respiratory infections

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aetiology and treatment of community-acquired pneumonia in adults: an historical perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro activity of sparfloxacin compared with ciprofloxacin and ofloxacin against respiratory tract pathogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of quinolone resistance in clinical isolates: accumulation of sparfloxacin and of fluoroquinolones of various hydrophobicity, and analysis of membrane composition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sparfloxacin for the treatment of community-acquired pneumonia: a pooled data analysis of two studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antimicrobial Resistance in Streptococcus pneumoniae: An Overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative efficacy of sparfloxacin in comparison with amoxycillin plus ofloxacin in the treatment of community-acquired pneumonia. French Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro activity of sparfloxacin compared with those of five other quinolones

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antimicrobial activity and spectrum of sparfloxacin tested against erythromycin-resistant Streptococcus pneumoniae isolates

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of new quinolones against ciprofloxacin-resistant staphylococci

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal elimination of sparfloxacin, fleroxacin, and ciprofloxacin in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sparfloxacin empirical therapy in community-acquired pneumonia. Results of a meta-analysis of 2 comparative studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro activity of sparfloxacin (AT-4140 and CI-978), a new quinolone antimicrobial agent, against Haemophilus and gram-positive cocci

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral empiric treatment of community-acquired pneumonia. A multicenter, double-blind, randomized study comparing sparfloxacin with roxithromycin. The Scandinavian Sparfloxacin Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

European Study Group on Antibiotic Breakpoints. Breakpoint determination: sparfloxacin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antimicrobial Resistance in Streptococcus pneumoniae: An Epidemiological Survey in France, 1970-1990

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postantibiotic sub-MIC effects of vancomycin, roxithromycin, sparfloxacin, and amikacin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular basis of quinolone action

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of sparfloxacin (AT-4140), PD127391 and PD131628 against Legionella spp

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro studies with five quinolones: evidence for changes in relative potency as quinolone resistance rises

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Management of community-acquired pneumonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of clinical resistance to fluoroquinolones in Staphylococcus aureus

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of action of quinolones against Escherichia coli DNA gyrase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of community-acquired pneumonia: a randomized comparison of sparfloxacin, amoxycillin-clavulanic acid and erythromycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of new quinolones in the treatment of respiratory tract infections

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The concentration of sparfloxacin in lung tissues after single and multiple oral doses

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and inflammatory fluid penetration of sparfloxacin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Guidelines for the management of community-acquired pneumonia in adults admitted to hospital. The British Thoracic Society

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognosis and outcomes of patients with community-acquired pneumonia. A meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of sparfloxacin on Staphylococcus aureus adhesiveness and phagocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Study design, methodology and statistical analyses in the clinical development of sparfloxacin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetics of sparfloxacin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety profile of sparfloxacin in the treatment of respiratory tract infections

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rifabutin and sparfloxacin but not azithromycin inhibit binding of Mycobacterium avium complex to HT-29 intestinal mucosal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antimicrobial activity of sparfloxacin, a new quinolone

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In-vitro activity of sparfloxacin in comparison with currently available antimicrobials against respiratory tract pathogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of DU-6859a, ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and OPC-17116 against 112 penicillin-susceptible and -resistant pneumococci

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cimetidine does not alter sparfloxacin pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative in vitro antibacterial activity of sparfloxacin (AT-4140; RP 64206), a new quinolone

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of ferrous sulfate on the absorption of sparfloxacin in healthy volunteers and rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro activity of AT-4140 against quinolone- and methicillin-resistant Staphylococcus aureus

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Legionella pneumophila in guinea pig peritoneal macrophages by new quinolone, macrolide and other antimicrobial agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Guidelines for the initial management of adults with community-acquired pneumonia: diagnosis, assessment of severity, and initial antimicrobial therapy. American Thoracic Society. Medical Section of the American Lung Association

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effects of ciprofloxacin and sparfloxacin on DNA gyrase purified from fluoroquinolone-resistant strains of methicillin-resistant Staphylococcus aureus

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of the fluoroquinolones on gastrointestinal flora.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of a new quinolone, sparfloxacin, on the pharmacokinetics of theophylline in asthmatic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-level fluoroquinolone resistance in Streptococcus pneumoniae requires mutations in parC and gyrA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative safety and efficacy of sparfloxacin in the treatment of acute exacerbations of chronic obstructive pulmonary disease: a double-blind, randomised, parallel, multicentre study

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidemiological features and chemotherapy of community-acquired respiratory tract infections

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug interactions with quinolone antibacterials

1 reference

https://pubmed.ncbi.nlm.nih.gov/9098667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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