Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection (Q28338382)

2

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M A Jay

3

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M M Durkin

4

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J W Smith

Antimicrobial Agents and Chemotherapy

5

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language of work or name

English

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publication date

September 1987

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published in

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volume

31

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issue

9

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page(s)

1323-7

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cites work

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Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent

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Growth and serial passage of Pneumocystis carinii in the A549 cell line

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Adverse Reactions to Trimethoprim-Sulfamethoxazole in Patients with the Acquired Immunodeficiency Syndrome

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Complications of co-trimoxazole in treatment of AIDS-associated Pneumocystis carinii pneumonia in homosexual men

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Pentamidine for the treatment of Pneumocystis carinii pneumonia and other protozoal diseases

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Dapsone-trimethoprim for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome

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Cultivation of Pneumocystis carinii with WI-38 cells

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Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine

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Pharmacology and toxicity of a potent "nonclassical" 2,4-diamino quinazoline folate antagonist, trimetrexate, in normal dogs.

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Successful treatment of lethal protozoal infections with the ornithine decarboxylase inhibitor, alpha-difluoromethylornithine.

2 June 2018

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2 June 2018

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Management of opportunistic infections complicating the acquired immunodeficiency syndrome

2 June 2018

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2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline (tmq), a potent non-classical folate antagonist inhibitor--I effect on dihydrofolate reductase and growth of rodent tumors in vitro and in vivo

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Phase I studies with trimetrexate: clinical pharmacology, analytical methodology, and pharmacokinetics

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12 December 2020

Latent Pneumocystis infection of rats, relapse, and chemotherapy

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Inhibition of histamine-metabolizing enzymes and elevation of histamine levels in tissues by lipid-soluble anticancer folate antagonists

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Fluorogenic substrate detection of viable intracellular and extracellular pathogenic protozoa

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12 December 2020