Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain (Q28343921)

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English	Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain	scientific article

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scholarly article

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Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain (English)

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based on heuristic

inferred from title

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based on heuristic

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author name string

N Serkova

1

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W Jacobsen

2

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C U Niemann

3

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L Litt

4

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L Z Benet

5

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D Leibfritz

6

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U Christians

7

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language of work or name

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publication date

July 2001

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British Journal of Pharmacology

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133

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6

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875-85

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Cyclosporine neurotoxicity: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

29 September 2017

Newer immunosuppressive drugs: a review.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

29 September 2017

Structure, function and regulation of pyruvate carboxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

29 September 2017

In vitro and in situ absorption of SDZ-RAD using a human intestinal cell line (Caco-2) and a single pass perfusion model in rats: comparison with rapamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

29 September 2017

Modulation of energy status and cytotoxicity induced by FK506 and cyclosporin A in a renal epithelial cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

29 September 2017

Cyclosporine neurotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

29 September 2017

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

29 September 2017

Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

29 September 2017

Regulation of cellular energy metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

29 September 2017

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

29 September 2017

Fine control of the conversion of pyruvate (phosphoenolpyruvate) to oxaloacetate in various species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

29 September 2017

Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

29 September 2017

Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

2 June 2018

The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

2 June 2018

Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

2 June 2018

Mitochondrial permeability transition in the central nervous system: induction by calcium cycling-dependent and -independent pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

2 June 2018

Evaluation of the effects of immunosuppressants on neuronal and glial cells in vitro by multinuclear magnetic resonance spectroscopy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

2 June 2018

Cyclosporine nephrotoxicity: attenuation by an antioxidant-inhibitor of lipid peroxidation in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

2 June 2018

FK506 increases permeability in rat intestine by inhibiting mitochondrial function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

2 June 2018

Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

27 November 2018

Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

27 November 2018

The effect of tacrolimus (FK506) on intestinal barrier function and cellular energy production in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

27 November 2018

Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572850

27 November 2018

Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/11454661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absorption and intestinal metabolism of SDZ-RAD and rapamycin in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11454661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11454661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of cyclosporine on oxidative phosphorylation and adenylate energy charge of regenerating rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/11454661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporine a inhibits ATP net uptake of rat kidney mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/11454661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trimetazidine reverses calcium accumulation and impairment of phosphorylation induced by cyclosporine A in isolated rat liver mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/11454661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic effects of cyclosporine and rapamycin in a chronic nephrotoxicity model

1 reference

https://pubmed.ncbi.nlm.nih.gov/11454661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitive and specific quantification of sirolimus (rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/11454661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the pharmacokinetic interaction between orally administered sirolimus and cyclosporine on the synergistic prolongation of heart allograft survival in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11454661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin inhibits aldolase A expression during human lymphocyte activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11454661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The synergistic effects of cyclosporine and sirolimus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11454661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporine A-induced oxidative stress in rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11454661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SDZ RAD, a new rapamycin derivative: synergism with cyclosporine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11454661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative tissue distributions of cyclosporine and sirolimus after concomitant peroral administration to the rat: evidence for pharmacokinetic interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/11454661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperlipidemia in renal transplant recipients treated with sirolimus (rapamycin)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11454661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJP.0704142

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