Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity (Q28344371)

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M K Chang

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L K Curtiss

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W Palinski

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G J Silverman

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J L Witztum

Journal of Clinical Investigation

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language of work or name

English

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publication date

June 2000

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published in

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volume

105

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page(s)

1731-40

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issue

12

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cites work

The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and beta2 glycoprotein 1 (and other proteins)

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Origin of murine B cell lineages

20 March 2017

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B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development.

6 April 2017

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The chosen few? Positive selection and the generation of naive B lymphocytes

29 September 2017

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Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition

29 September 2017

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Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins

29 September 2017

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B-1 cell development: evidence for an uncommitted immunoglobulin (Ig)M+ B cell precursor in B-1 cell differentiation

29 September 2017

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Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions

29 September 2017

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Oxidized phosphatidylcholines that modify proteins. Analysis by monoclonal antibody against oxidized low density lipoprotein

29 September 2017

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Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids. Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein

29 September 2017

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Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma

29 September 2017

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Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis

29 September 2017

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Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae

29 September 2017

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The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site

29 September 2017

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Heavy-chain class switch does not terminate somatic mutation

29 September 2017

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Antigen binding and idiotype analysis of antibodies obtained after electroporation of heavy and light chain genes encoding phosphocholine-specific antibodies: a model for T15-idiotype dominance

29 September 2017

1 reference

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The dual phases of the response to neonatal exposure to a VH family-restricted staphylococcal B cell superantigen.

29 September 2017

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ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.

2 June 2018

1 reference

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Monoclonal vs. heterogeneous anti-H-8 antibodies in the analysis of the anti-phosphorylcholine response in BALB/c mice

2 June 2018

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T cell-dependent antibody production by Ly-1 B cells

2 June 2018

1 reference

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The frequency of phosphorylcholine-specific B cells in conventional and germfree BALB/C mice

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378505

Immunization of LDL receptor-deficient mice with homologous malondialdehyde-modified and native LDL reduces progression of atherosclerosis by mechanisms other than induction of high titers of antibodies to oxidative neoepitopes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378505

An unbiased analysis of V(H)-D-J(H) sequences from B-1a, B-1b, and conventional B cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378505

Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378505

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378505

Rat anti-T15 monoclonal antibodies with specificity for VH- and VH-VL epitopes

27 November 2018

1 reference

12 December 2020

Increased autoantibody titers against epitopes of oxidized LDL in LDL receptor-deficient mice with increased atherosclerosis

1 reference

12 December 2020

Phosphorylcholine: friend or foe of the immune system?

1 reference

12 December 2020

Positive selection of natural autoreactive B cells

1 reference

12 December 2020

All T15 Id-positive antibodies (but not the majority of VHT15+ antibodies) are produced by peritoneal CD5+ B lymphocytes

1 reference

12 December 2020

Clonal nature of the immune response to phosphocholine. VII. Evidence throughout inbred mice for molecular similarities among antibodies bearing the T15 idiotype

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI8472

1 reference

1023892

1023892

1 reference

1 reference

1 reference