Roles of the juxtamembrane and extracellular domains of angiotensin-converting enzyme in ectodomain shedding (Q28345230)

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A J Chubb

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S L Schwager

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M R Ehlers

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E D Sturrock

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N M Hooper

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Susan PANG

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Anthony J. CHUBB

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Sylva L. U. SCHWAGER

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Mario R. W. EHLERS

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Edward D. STURROCK

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Nigel M. HOOPER

Regulated cleavage of a contact-mediated axon repellent

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language of work or name

English

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publication date

15 August 2001

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published in

Biochemical Journal

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volume

358

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issue

Pt 1

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1

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page(s)

185-92

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185

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cites work

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Internally quenched fluorogenic substrates for angiotensin I-converting enzyme

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A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester

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Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning

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The two homologous domains of human angiotensin I-converting enzyme are both catalytically active

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Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme

20 March 2017

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A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase

20 March 2017

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Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites.

29 September 2017

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Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding.

29 September 2017

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The distal ectodomain of angiotensin-converting enzyme regulates its cleavage-secretion from the cell surface

29 September 2017

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Proteolytic release of membrane-bound angiotensin-converting enzyme: role of the juxtamembrane stalk sequence

29 September 2017

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Angiotensin-converting enzyme: new concepts concerning its biological role

29 September 2017

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cDNA cloning and expression in Xenopus laevis oocytes of pig renal dipeptidase, a glycosyl-phosphatidylinositol-anchored ectoenzyme

29 September 2017

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Transcription of testicular angiotensin-converting enzyme (ACE) is initiated within the 12th intron of the somatic ACE gene

29 September 2017

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Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins

29 September 2017

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Spontaneous solubilization of membrane-bound human testis angiotensin-converting enzyme expressed in Chinese hamster ovary cells

29 September 2017

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Angiotensin converting enzyme: Implications from molecular biology for its physiological functions

29 September 2017

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Recognition sequences and structural elements contribute to shedding susceptibility of membrane proteins.

29 September 2017

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Peptidase specificity characterization of C- and N-terminal catalytic sites of angiotensin I-converting enzyme.

2 June 2018

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Modulation of juxtamembrane cleavage ("shedding") of angiotensin-converting enzyme by stalk glycosylation: evidence for an alternative shedding protease.

2 June 2018

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Multiple factors determine the selection of the ectodomain cleavage site of human cell surface macrophage colony-stimulating factor

2 June 2018

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Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase

2 June 2018

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Angiotensin-converting enzyme secretase is inhibited by zinc metalloprotease inhibitors and requires its substrate to be inserted in a lipid bilayer

2 June 2018

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Membrane protein secretases

2 June 2018

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Characterization of a secretase activity which releases angiotensin-converting enzyme from the membrane

2 June 2018

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Structures of the glycosyl-phosphatidylinositol anchors of porcine and human renal membrane dipeptidase. Comprehensive structural studies on the porcine anchor and interspecies comparison of the glycan core structures.

2 June 2018

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Ectoenzymes of the kidney microvillar membrane. Affinity purification, characterization and localization of the phospholipase C-solubilized form of renal dipeptidase

2 June 2018

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Renal dipeptidase is one of the membrane proteins released by phosphatidylinositol-specific phospholipase C.

2 June 2018

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Angiotensin-converting enzyme of the human small intestine. Subunit and quaternary structure, biosynthesis and membrane association

2 June 2018

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Shedding of interleukin-6 receptor and tumor necrosis factor alpha. Contribution of the stalk sequence to the cleavage pattern of transmembrane proteins

2 June 2018

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Comparison of the glycosyl-phosphatidylinositol cleavage/attachment site between mammalian cells and parasitic protozoa.

27 November 2018

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Phorbol ester-induced juxtamembrane cleavage of angiotensin-converting enzyme is not inhibited by a stalk containing intrachain disulfides.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222046

The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor-alpha convertase

27 November 2018

1 reference

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Site-directed mutagenesis of conserved cysteine residues in porcine membrane dipeptidase. Cys 361 alone is involved in disulfide-linked dimerization.

27 November 2018

1 reference

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Isolation of two differentially glycosylated forms of peptidyl-dipeptidase A (angiotensin converting enzyme) from pig brain: a re-evaluation of their role in neuropeptide metabolism

27 November 2018

1 reference

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Angiotensin-converting enzyme: zinc- and inhibitor-binding stoichiometries of the somatic and testis isozymes

27 November 2018

1 reference

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Role of the Juxtamembrane Domains of the Transforming Growth Factor-α Precursor and the β-Amyloid Precursor Protein in Regulated Ectodomain Shedding

27 November 2018

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12 December 2020

An essential role for ectodomain shedding in mammalian development

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12 December 2020

ADAMs: focus on the protease domain

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12 December 2020

Unaltered cleavage and secretion of angiotensin-converting enzyme in tumor necrosis factor-alpha-converting enzyme-deficient mice

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12 December 2020