Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production (Q28345388)

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English	Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production	scientific article

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scholarly article

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Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production (English)

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author name string

C Wu

1

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D A Okar

2

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C B Newgard

3

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A J Lange

4

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language of work or name

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publication date

January 2001

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Journal of Clinical Investigation

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107

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1

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91-8

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Fructose-2,6-bisphosphate and control of carbohydrate metabolism in eukaryotes

1 reference

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20 March 2017

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme

2 references

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20 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

6 April 2017

Phosphofructokinase 2: the enzyme that forms fructose 2,6-bisphosphate from fructose 6-phosphate and ATP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

20 March 2017

Hormonal regulation of hepatic gluconeogenesis and glycolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

20 March 2017

Rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Properties of phospho- and dephospho- forms and of two mutants in which Ser32 has been changed by site-directed mutagenesis

1 reference

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20 March 2017

Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

20 March 2017

Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

20 March 2017

Metabolic engineering with recombinant adenoviruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

29 September 2017

Regulation of glucose production by the liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

29 September 2017

Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo

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29 September 2017

Adenovirus-mediated transfer of a modified human proinsulin gene reverses hyperglycemia in diabetic mice.

1 reference

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29 September 2017

Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

29 September 2017

Correction of diabetic alterations by glucokinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

29 September 2017

Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

29 September 2017

Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

29 September 2017

Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

29 September 2017

13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

29 September 2017

Use of recombinant adenovirus for metabolic engineering of mammalian cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

29 September 2017

Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-biphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

29 September 2017

Assessment of insulin action in insulin-dependent diabetes mellitus using [6(14)C]glucose, [3(3)H]glucose, and [2(3)H]glucose. Differences in the apparent pattern of insulin resistance depending on the isotope used

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

29 September 2017

Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

29 September 2017

Hormonal modulation of key hepatic regulatory enzymes in the gluconeogenic/glycolytic pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

29 September 2017

Hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Use of site-directed mutagenesis to evaluate the roles of His-258 and His-392 in catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

29 September 2017

Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells. Paradoxical effect on Fru-2,6-P2 levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

2 June 2018

Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

2 June 2018

Rat hepatic 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase: A unique bifunctional enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

2 June 2018

Induction of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase mRNA by refeeding and insulin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

2 June 2018

Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=198549

27 November 2018

Oral administration of vanadate to diabetic rats restores liver 6-phosphofructo-2-kinase content and mRNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CS-045, a new oral antidiabetic agent, stimulates fructose-2,6-bisphosphate production in rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like actions of tungstate in diabetic rats. Normalization of hepatic glucose metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-stimulated synthesis of fructose 2,6-bisphosphate in rat liver. Dephosphorylation of fructose 6-phosphate, 2-kinase:fructose 2,6-bisphosphatase and activation by a sugar phosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like effects of vanadate on rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase mRNA and protein inductions in diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fructose 2,6-bisphosphate. A new activator of phosphofructokinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-bisphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of "activation factor" for phosphofructokinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of diabetes, insulin, starvation, and refeeding on the level of rat hepatic fructose 2,6-bisphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation by glucagon of hepatic pyruvate kinase, 6-phosphofructo 1-kinase, and fructose-1,6-bisphosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of proteolysis and protein modification on the activities of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like effects of vanadate on glucokinase activity and fructose 2,6-bisphosphate levels in the liver of diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo effects of vanadate on hepatic glycogen metabolizing and lipogenic enzymes in insulin-dependent and insulin-resistant diabetic animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a role of glucose-induced translocation of glucokinase in the control of hepatic glycogen synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulinlike effects of vanadate on hepatic glycogen metabolism in nondiabetic and streptozocin-induced diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134184

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI11103

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