A novel doxorubicin-glucuronide prodrug DOX-GA3 for tumour-selective chemotherapy: distribution and efficacy in experimental human ovarian cancer (Q28350934)

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English	A novel doxorubicin-glucuronide prodrug DOX-GA3 for tumour-selective chemotherapy: distribution and efficacy in experimental human ovarian cancer	scientific article

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scholarly article

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A novel doxorubicin-glucuronide prodrug DOX-GA3 for tumour-selective chemotherapy: distribution and efficacy in experimental human ovarian cancer (English)

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author name string

P H Houba

1

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E Boven

2

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I H van der Meulen-Muileman

3

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R G Leenders

4

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J W Scheeren

5

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H M Pinedo

6

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H J Haisma

7

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language of work or name

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publication date

February 2001

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British Journal of Cancer

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84

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4

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550-7

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The anthracyclines: will we ever find a better doxorubicin?

1 reference

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20 March 2017

The efficacy of the anthracycline prodrug daunorubicin-GA3 in human ovarian cancer xenografts.

1 reference

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29 September 2017

Construction and characterization of a fusion protein of single-chain anti-CD20 antibody and human beta-glucuronidase for antibody-directed enzyme prodrug therapy

1 reference

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29 September 2017

The anti-tumour effects of the prodrugs N-l-leucyl-doxorubicin and vinblastine-isoleucinate in human ovarian cancer xenografts

1 reference

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29 September 2017

Characterization of a human ovarian carcinoma cell line (NIH:OVCAR-3) with androgen and estrogen receptors.

1 reference

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2 June 2018

The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters

1 reference

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2 June 2018

Doxorubicin compared with related compounds in a nude mouse model for human ovarian cancer

1 reference

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2 June 2018

Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.

1 reference

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Cure of Mice bearing Advanced Plasma Cell Tumours with Aniline Mustard : the Relationship between Glucuronidase Activity and Tumour Sensitivity

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Novel anthracycline-spacer-beta-glucuronide,-beta-glucoside, and -beta-galactoside prodrugs for application in selective chemotherapy

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12 December 2020

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Purification and chemical properities of mouse liver lysosomal (L form) beta-glucuronidase

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Therapeutic trial of aniline mustard in patients with advanced cancer. Comparison of therapeutic response with cytochemical assessment of tumor cell beta-glucuronidase activity

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Accumulation and metabolism of new anthracycline derivatives in the heart after IV injection into mice

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Preclinical phase II studies in human tumor lines: a European multicenter study

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Human ovarian cancer xenografts in nude mice: characterization and analysis of antigen expression

1 reference

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Simple and sensitive quantification of anthracyclines in mouse atrial tissue using high-performance liquid chromatography and fluorescence detection

1 reference

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Plasma pharmacokinetics and pharmacodynamics of a new prodrug N-l-leucyldoxorubicin and its metabolites in a phase I clinical trial

1 reference

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12 December 2020

based on heuristic

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Tumor-selective prodrug activation by fusion protein-mediated catalysis

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy

1 reference

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Characterization of novel anthracycline prodrugs activated by human beta-glucuronidase for use in antibody-directed enzyme prodrug therapy

1 reference

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12 December 2020

based on heuristic

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Histochemistry of therapeutically relevant enzymes in human tumours transplanted into severe combined immunodeficient (SCID) mice: nitric oxide synthase-associated diaphorase, beta-D-glucuronidase and non-specific alkaline phosphatase

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution and pharmacokinetics of the prodrug daunorubicin-GA3 in nude mice bearing human ovarian cancer xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/11207053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1054/BJOC.2000.1640

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