Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo (Q28353986)

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R C Benyon

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N Trim

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R Hadwin

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B H Grove

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M J Arthur

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E N Unemori

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J P Iredale

Relaxin: a pleiotropic hormone

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language of work or name

English

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publication date

October 2001

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published in

Gut

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volume

49

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issue

4

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page(s)

577-83

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cites work

1 reference

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Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

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Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells

29 September 2017

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Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo

29 September 2017

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Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies

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Human relaxins: chemistry and biology

29 September 2017

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Hepatic lipocytes: the principal collagen-producing cells of normal rat liver

29 September 2017

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Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen

29 September 2017

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Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo

29 September 2017

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Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver

29 September 2017

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Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver.

29 September 2017

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Reestablishment of cell polarity of rat hepatocytes in primary culture

2 June 2018

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Utilization of the releaxed symphysis pubis of guinea pigs for clues to the mechanism of ovulation

2 June 2018

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Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor

2 June 2018

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Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts

2 June 2018

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Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression

2 June 2018

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Transforming growth factor-beta is a potent inhibitor of basal and stimulated relaxin release by porcine luteal cells maintained in monolayer culture

2 June 2018

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Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis.

2 June 2018

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Human relaxin decreases collagen accumulation in vivo in two rodent models of fibrosis

27 November 2018

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Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments.

27 November 2018

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Rat hepatic lipocytes synthesize and secrete transin (stromelysin) in early primary culture.

27 November 2018

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SIRIUS RED F3BA AS A STAIN FOR CONNECTIVE TISSUE

27 November 2018

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12 December 2020

Lymphocyte modulation of fibroblast function in vitro: stimulation and inhibition of collagen production by different effector molecules

1 reference

12 December 2020

Regulatory influence of relaxin on human cervical and uterine connective tissue

1 reference

12 December 2020

The effect of oestrogen and relaxin on uterine and cervical enzymes: collagenase, proteoglycanase and beta-glycuronidase

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12 December 2020

Relaxin alone and in conjunction with interferon-gamma decreases collagen synthesis by cultured human scleroderma fibroblasts

1 reference

12 December 2020

Tissue inhibitor of metalloproteinase-I and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes

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12 December 2020

The plasminogen-activating system in hepatic stellate cells

1 reference

12 December 2020

Pathogenesis of liver fibrosis

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12 December 2020

An autocrine/paracrine role of human decidual relaxin. II. Stromelysin-1 (MMP-3) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1)

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12 December 2020

Effect of relaxin on tissue inhibitor of metalloproteinase-1 and -2 in the porcine uterus and cervix

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12 December 2020

A simple, rapid, and sensitive DNA assay procedure

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12 December 2020

Identifiers

DOI

10.1136/GUT.49.4.577

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4968317

4968317

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1 reference

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