Demonstration of viral thymidine kinase inhibitor and its effect on deoxynucleotide metabolism in cells infected with herpes simplex virus (Q28360575)

1

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S P Grill

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G E Dutschman

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R A Sharma

4

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M Bobek

5

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Y C Cheng

Antimicrobial Agents and Chemotherapy

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language of work or name

English

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publication date

March 1987

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published in

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volume

31

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issue

3

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page(s)

368-74

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cites work

Anti-herpes simplex virus and anti-human cell growth activity of E-5-propenyl-2'-deoxyuridine and the concept of selective protection in antivirus chemotherapy

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Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo

20 March 2017

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

20 March 2017

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Acquisition of thymidine kinase activity by herpes simplex infected mouse fibroblast cells

20 March 2017

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Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolates

29 September 2017

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Drug resistance patterns of herpes simplex virus isolates from patients treated with acyclovir

29 September 2017

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An enzymatic method for distinguishing deoxyuridine and deoxythymidine nucleotide pools and its application for determining ribonucleotide reductase activity

29 September 2017

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Human thymidylate synthetase derived from blast cells of patients with acture myelocytic leukemia. Purification and chracterization

29 September 2017

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Induction of thymidine kinase and DNase in varicella-zoster virus-infected cells and kinetic properties of the virus-induced thymidine kinase

29 September 2017

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Trigeminal Ganglion Infection by Thymidine Kinase-Negative Mutants of Herpes Simplex Virus

29 September 2017

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A rational approach to the development of antiviral chemotherapy: alternative substrates of herpes simplex virus Type 1 (HSV-1) and Type 2 (HSV-2) thymidine kinase (TK)

29 September 2017

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Deoxythymidine kinase induced in heLa TK− cells by herpes simplex virus type I and type II. Substrate specificity and kinetic behaviour

29 September 2017

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Deoxythymidine kinase induced in HeLa TK- cells by herpes simplex virus type I and type II. II. Purification and characterization

29 September 2017

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An assay for pyrimidine deoxyribonucleoside kinase using γ-32P-labeled ATP

29 September 2017

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A simple cytochemical technique for demonstration of DNA in cells infected with mycoplasmas and viruses

29 September 2017

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Selective inhibition of DNA replication in herpes simplex virus infected cells by 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine

29 September 2017

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Inhibition of purified human and herpes simplex virus-induced DNA polymerases by 9-(2-hydroxyethoxymethyl)guanine triphosphate. Effects on primer-template function

2 June 2018

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HeLa cells resistant to bromodeoxyuridine and deficient in thymidine kinase activity.

2 June 2018

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A new rapid assay for measuring deoxycytidylate- and deoxythymidylate-kinase activities.

2 June 2018

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A virus-specific thymidine kinase in BHK-21 cells infected with herpes simplex virus

2 June 2018

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The sources of thymidine nucleotides for virus DNA synthesis in herpes simplex virus type 2-infected cells.

2 June 2018

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Acetylenic nucleosides. 1. Synthesis of 1-(5,6-Dideoxy-.beta.-D-ribo-hex-5-ynofuranosyl)uracil and 1-(2,5,6-trideoxy-.beta.-D-erythro-hex-5-ynofuranosyl)-5-methyluracil

2 June 2018

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Adenosine phosphorylase-mediated nucleoside toxicity. Application towards the detection of mycoplasmal infection in mammalian cell cultures

2 June 2018

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Interaction of herpes simplex virus-induced DNA polymerase with 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate.

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=174734

Characterization of Abnormal Thymidine Kinases Induced by Drug-resistant Strains of Herpes Simplex Virus Type 1

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=174734

Isolation of bromovinyldeoxyuridine-resistant strains of herpes simplex virus and successful chemotherapy of mice infected with one such strain by using acyclovir

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=174734

Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=174734

Novel interaction of aphidicolin with herpes simplex virus DNA polymerase and polymerase-associated exonuclease

27 November 2018

1 reference

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An Isotopic Assay for Thymidylate Synthetase*

27 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/3034143