Inhibition of acetylcholine-activated K(+) currents by U73122 is mediated by the inhibition of PIP(2)-channel interaction (Q28362745)

1

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J B Youm

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S Y Ryu

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Y E Earm

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W K Ho

British Journal of Pharmacology

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language of work or name

English

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publication date

November 2001

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published in

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volume

134

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issue

5

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page(s)

1066-72

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cites work

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Identification of domains conferring G protein regulation on inward rectifier potassium channels

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Depletion of phosphatidylinositol 4,5-bisphosphate by activation of phospholipase C-coupled receptors causes slow inhibition but not desensitization of G protein-gated inward rectifier K+ current in atrial myocytes.

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Two compounds commonly used for phospholipase C inhibition activate the nuclear estrogen receptors

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Activation of the atrial KACh channel by the betagamma subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates

29 September 2017

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Purification, characterization, and synthesis of an inward-rectifier K+ channel inhibitor from scorpion venom

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Na+ activation of the muscarinic K+ channel by a G-protein-independent mechanism

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G beta gamma directly binds to the carboxyl terminus of the G protein-gated muscarinic K+ channel, GIRK1.

29 September 2017

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The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.

29 September 2017

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Skeletal muscle ATP-sensitive K+ channels recorded from sarcolemmal blebs of split fibers: ATP inhibition is reduced by magnesium and ADP.

29 September 2017

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Gating of G protein-sensitive inwardly rectifying K+ channels through phosphatidylinositol 4,5-bisphosphate

29 September 2017

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Molecular determinants for sodium-dependent activation of G protein-gated K+ channels

2 June 2018

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U73122 and U73343 inhibit receptor-mediated phospholipase D activation downstream of phospholipase C in CHO cells.

2 June 2018

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Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma

2 June 2018

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Voltage-gated and inwardly rectifying potassium channels

2 June 2018

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Evidence that direct binding of Gβγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation

2 June 2018

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Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells

2 June 2018

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Positive cooperativity in activation of the cardiac muscarinic K+ channel by intracellular GTP.

2 June 2018

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Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness

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Phosphatidylinositol 4,5-bisphosphate is acting as a signal molecule in alpha(1)-adrenergic pathway via the modulation of acetylcholine-activated K(+) channels in mouse atrial myocytes

2 June 2018

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Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions.

27 November 2018

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Molecular mechanism for sodium-dependent activation of G protein-gated K+ channels.

27 November 2018

1 reference

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A snake toxin inhibitor of inward rectifier potassium channel ROMK1.

27 November 2018

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A novel high-affinity inhibitor for inward-rectifier K+ channels.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573039

The interaction of U-73122 with the histamine H1 receptor: implications for the use of U-73122 in defining H1 receptor-coupled signalling pathways

27 November 2018

1 reference

12 December 2020

Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart

1 reference

12 December 2020

G beta gamma binds directly to the G protein-gated K+ channel, IKACh

1 reference

12 December 2020

The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell

1 reference

12 December 2020

Nonselective effects of the putative phospholipase C inhibitor, U73122, on adenosine A1 receptor-mediated signal transduction events in Chinese hamster ovary cells

1 reference

12 December 2020

release_id5xly3ip5esdf3m2spipad7w4

Identifiers

DOI

10.1038/SJ.BJP.0704347

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Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/id5xly3ip5esdf3m2spipad7w4

24 November 2022