Characterization of PHEX endopeptidase catalytic activity: identification of parathyroid-hormone-related peptide107-139 as a substrate and osteocalcin, PPi and phosphate as inhibitors (Q28363247)

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English	Characterization of PHEX endopeptidase catalytic activity: identification of parathyroid-hormone-related peptide107-139 as a substrate and osteocalcin, PPi and phosphate as inhibitors	scientific article

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6 November 2019

Characterization of PHEX endopeptidase catalytic activity: identification of parathyroid-hormone-related peptide107-139 as a substrate and osteocalcin, PPi and phosphate as inhibitors (English)

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6 November 2019

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G Boileau

1

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6 November 2019

H S Tenenhouse

2

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6 November 2019

L Desgroseillers

3

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P Crine

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1 May 2001

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6 November 2019

Biochemical Journal

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6 November 2019

355

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6 November 2019

707-713

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6 November 2019

Pt 3

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6 November 2019

Organization and chromosomal localization of the human ECEL1 (XCE) gene encoding a zinc metallopeptidase involved in the nervous control of respiration

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20 March 2017

Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon

1 reference

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X-linked hypophosphataemia: a homologous disorder in humans and mice

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20 March 2017

Cloning of human PEX cDNA. Expression, subcellular localization, and endopeptidase activity

1 reference

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20 March 2017

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1 reference

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Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11

1 reference

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Damage-induced neuronal endopeptidase (DINE) is a unique metallopeptidase expressed in response to neuronal damage and activates superoxide scavengers

1 reference

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20 March 2017

Rat endothelin-converting enzyme-1 forms a dimer through Cys412 with a similar catalytic mechanism and a distinct substrate binding mechanism compared with neutral endopeptidase-24.11

1 reference

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20 March 2017

Developmental expression and tissue distribution of Phex protein: effect of the Hyp mutation and relationship to bone markers.

1 reference

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29 September 2017

Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family

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29 September 2017

Coordinated maturational regulation of PHEX and renal phosphate transport inhibitory activity: evidence for the pathophysiological role of PHEX in X-linked hypophosphatemia

1 reference

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Hydrolysis of peptide hormones by endothelin-converting enzyme-1. A comparison with neprilysin

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In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor

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29 September 2017

Cloning and sequencing of human PEX from a bone cDNA library: evidence for its developmental stage-specific regulation in osteoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221786

29 September 2017

Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice

1 reference

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Increased bone formation in osteocalcin-deficient mice.

1 reference

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29 September 2017

Defining the roles of parathyroid hormone-related protein in normal physiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221786

29 September 2017

Expression of parathyroid hormone-related protein in cells of osteoblast lineage

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221786

29 September 2017

Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology

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29 September 2017

Hypophosphatasia and the role of alkaline phosphatase in skeletal mineralization

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Healing of rickets with phosphate supplementation in the hypophosphatemic male mouse

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29 September 2017

Association of inorganic-pyrophosphatase activity with human alkaline-phosphatase preparations

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29 September 2017

The purification and specificity of a neutral endopeptidase from rabbit kidney brush border

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221786

29 September 2017

Expression of neutral endopeptidase (enkephalinase) in heterologous COS-1 cells. Characterization of the recombinant enzyme and evidence for a glutamic acid residue at the active site

1 reference

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29 September 2017

A carboxyl-terminal peptide from the parathyroid hormone-related protein inhibits bone resorption by osteoclasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221786

29 September 2017

C-terminal parathyroid hormone-related protein inhibits proliferation and differentiation of human osteoblast-like cells

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2 June 2018

Secretion of a type II integral membrane protein induced by mutation of the transmembrane segment

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2 June 2018

cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in bone

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2 June 2018

Direct targeting of neutral endopeptidase (EC 3.4.24.11) to the apical cell surface of transfected LLC-PK1 cells and unpolarized secretion of its soluble form

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2 June 2018

Evidence that Asn542 of neprilysin (EC 3.4.24.11) is involved in binding of the P2' residue of substrates and inhibitors

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2 June 2018

Multiple mechanisms of protein insertion into and across membranes.

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2 June 2018

Fusion of a cleavable signal peptide to the ectodomain of neutral endopeptidase (EC 3.4.24.11) results in the secretion of an active enzyme in COS-1 cells.

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2 June 2018

Direct demonstration of a humorally-mediated inhibition of renal phosphate transport in the Hyp mouse

1 reference

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Phosphatonin--a new phosphaturetic hormone? (lessons from tumour-induced osteomalacia and X-linked hypophosphataemia)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11311133

12 December 2020

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inferred from PubMed ID database lookup

Construction, expression and characterization of a soluble form of human endothelin-converting-enzyme-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11311133

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of osteoblast proliferation by C-terminal fragments of parathyroid hormone-related protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11311133

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PHEXdb, a locus-specific database for mutations causing X-linked hypophosphatemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11311133

12 December 2020

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inferred from PubMed ID database lookup

Inhibition of hydroxyapatite crystal growth by bone-specific and other calcium-binding proteins

1 reference

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12 December 2020

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Cultured osteoblasts from normal and hypophosphatemic mice: calcitriol receptors and biological response to the hormone

1 reference

https://pubmed.ncbi.nlm.nih.gov/11311133

12 December 2020

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Molecular biology of blood groups: cloning the Kell gene

1 reference

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1 reference

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Molecular biology of hypophosphataemic rickets and oncogenic osteomalacia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11311133

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carboxyl-terminal peptides from parathyroid hormone-related protein stimulate osteoclast-like cell formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11311133

12 December 2020

based on heuristic

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Identifiers

10.1042/BJ3550707

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6 November 2019

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Europe PubMed Central

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6 November 2019

1 reference

Europe PubMed Central

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6 November 2019

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