Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene (Q28363368)

1

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L Diatchenko

2

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K M Scharff

4

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H Schober

5

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K Arlt

6

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B Zhumabayeva

7

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P D Siebert

8

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M Dietel

9

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R Schäfer

10

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C Sers

The American Journal of Pathology

11

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language of work or name

English

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publication date

November 2001

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published in

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volume

159

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issue

5

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page(s)

1635-43

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cites work

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Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases

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Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity.

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Tumor suppressor genes

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Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells

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Genetic alterations distinguish different types of ovarian tumors

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Ovarian cancer: loss of heterozygosity frequently occurs in the ATM gene, but structural alterations do not occur in this gene

7 January 2021

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Loss of heterozygosity on the long arm of human chromosome 7 in sporadic renal cell carcinomas

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Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1)

7 January 2021

1 reference

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Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy

7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11696424

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Caveolin-1 expression in clinically confined human prostate cancer: a novel prognostic marker

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11696424

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/S0002-9440(10)63010-6

1 reference

4308531

4308531

1 reference

1 reference

1 reference