Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species (Q28365278)

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English	Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species	scientific article

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scholarly article

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Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species (English)

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reactive oxygen species

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author name string

D A Fennell

1

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M Corbo

2

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A Pallaska

3

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F E Cotter

4

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language of work or name

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publication date

18 May 2001

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British Journal of Cancer

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84

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10

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1397-404

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Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

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Benzodiazepine receptor agonists modulate thymocyte apoptosis through reduction of the mitochondrial transmembrane potential

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Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

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Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis

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Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier

1 reference

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The Ca2+-induced membrane transition in mitochondria. II. Nature of the Ca2+ trigger site

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Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells

1 reference

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The effects of superoxide and the peripheral benzodiazepine receptor ligands on the mitochondrial processing of manganese-dependent superoxide dismutase

1 reference

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1 reference

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1 reference

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Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

1 reference

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Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding

1 reference

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1 reference

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Photodynamic tumor therapy: mitochondrial benzodiazepine receptors as a therapeutic target.

1 reference

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2 June 2018

Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites.

1 reference

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2 June 2018

Mitochondrial membrane potential monitored by JC-1 dye.

1 reference

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Cell surface expression of heat shock proteins in dog neutrophils induced by mitochondrial benzodiazepine receptor ligands.

1 reference

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The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents.

1 reference

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Peripheral benzodiazepine binding sites: Effect of PK 11195, 1-(2-chlorophenyl)-n-methyl-(1-methylpropyl)-3 isoquinolinecarboxamide

1 reference

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The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane.

1 reference

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Methods and mechanisms in electrodermal omission responding: a commentary on stimulus omission and the orienting response by Barry and O'Gorman.

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Peripheral benzodiazepine induces morphological changes and proliferation of mitochondria in glioma cells

1 reference

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Stochastic modeling of apoptosis tolerance distributions measured by multivariate flow analysis of human leukemia cells.

1 reference

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PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection.

1 reference

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Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone.

1 reference

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Peripheral benzodiazepine stimulates secretion of growth hormone and mitochondrial proliferation in pituitary tumour GH3 cells.

1 reference

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1 reference

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Mitochondrial benzodiazepine receptors mediate inhibition of mitochondrial respiratory control

1 reference

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Effect of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide (PK11195), a specific ligand of the peripheral benzodiazepine receptor, on the lipid fluidity of mitochondria in human glioma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11355954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/11355954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and biology of a 7-nitro-2,1,3-benzoxadiazol-4-yl derivative of 2-phenylindole-3-acetamide: a fluorescent probe for the peripheral-type benzodiazepine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11355954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Mr 18,000 subunit of the peripheral-type benzodiazepine receptor exhibits both benzodiazepine and isoquinoline carboxamide binding sites in the absence of the voltage-dependent anion channel or of the adenine nucleotide carrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/11355954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1054/BJOC.2001.1788

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