Analgesic activity of a novel use-dependent sodium channel blocker, crobenetine, in mono-arthritic rats (Q28366060)

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A J Carter

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M Grauert

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F Cervero

British Journal of Pharmacology

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language of work or name

English

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publication date

December 2001

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published in

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volume

134

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page(s)

1742-8

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issue

8

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cites work

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Involvement of Na+ channels in pain pathways

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Tetrodotoxin-resistant action potentials in dorsal root ganglion neurons are blocked by local anesthetics

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The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

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Alteration of descending modulation of nociception during the course of monoarthritis in the rat.

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PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade.

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Neuropathic pain can be relieved by drugs that are use-dependent sodium channel blockers: lidocaine, carbamazepine, and mexiletine

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Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons.

27 November 2018

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Development of inflammatory hypersensitivity and augmentation of sodium channels in rat dorsal root ganglia.

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SNS Na+ channel expression increases in dorsal root ganglion neurons in the carrageenan inflammatory pain model.

27 November 2018

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Correlation between electrophysiological effects of mexiletine and ischemic protection in central nervous system white matter.

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Different time-courses of i.v. lidocaine effect on ganglionic and spinal units in neuropathic rats.

27 November 2018

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Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats

27 November 2018

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A comparison of the action of mexiletine and morphine in rodent models of acute and chronic pain

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Efficacy and safety of meloxicam in patients with rheumatoid arthritis

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The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization

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Inflammation reveals inhibition of noxious responses of rat spinal neurones by carbamazepine

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Analgesic activity of the novel COX-2 preferring NSAID, meloxicam in mono-arthritic rats: Central and peripheral components

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A limited arthritic model for chronic pain studies in the rat

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Systemic mexiletine relieves chronic allodynialike symptoms in rats with ischemic spinal cord injury

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Functional and metabolic effects of mexiletine in the rat heart-lung preparation

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