Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886 (Q28366307)

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S S Biswal

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E La

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P Thuillier

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K Datta

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S M Fischer

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J P Vanden Heuvel

Protein measurement with the Folin phenol reagent

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language of work or name

English

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publication date

15 June 2001

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published in

Biochemical Journal

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volume

356

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issue

Pt 3

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page(s)

899-906

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cites work

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5-Lipoxygenase-activating protein (FLAP)

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Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

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An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

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Expression of peroxisome proliferator-activated receptors (PPARS) in human astrocytic cells: PPARgamma agonists as inducers of apoptosis

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The 5-lipoxygenase-activating protein (FLAP) inhibitor, MK886, induces apoptosis independently of FLAP.

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Peroxisome proliferator-activated receptors: a critical link among fatty acids, gene expression and carcinogenesis

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Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis

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PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A.

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A 5-lipoxygenase inhibitor at micromolar concentration raises intracellular calcium in U937 cells prior to their physiologic cell death

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Induction of apoptosis in blood cells from a patient with acute myelogenous leukemia by SC41661A, a selective inhibitor of 5-lipoxygenase

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Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPARalpha and TNFalpha.

29 September 2017

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Chemical probes that differentially modulate peroxisome proliferator-activated receptor alpha and BLTR, nuclear and cell surface receptors for leukotriene B(4).

2 June 2018

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A relationship between 5-lipoxygenase-activating protein and bcl-xL expression in murine pro-B lymphocytic FL5.12 cells

2 June 2018

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Effect of rodent hepatocarcinogenic peroxisome proliferators on fatty acyl-CoA oxidase, DNA synthesis, and apoptosis in cultured human and rat hepatocytes

2 June 2018

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Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha).

2 June 2018

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Role of membrane-associated and cytoplasmic fatty acid-binding proteins in cellular fatty acid metabolism

2 June 2018

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Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay

2 June 2018

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Non-genotoxic hepatocarcinogenesis: suppression of apoptosis by peroxisome proliferators

2 June 2018

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Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione peroxidase deficiency.

2 June 2018

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Properties of carcinogen altered mouse epidermal cells resistant to calcium-induced terminal differentiation

2 June 2018

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Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor

2 June 2018

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Perturbations in the control of cellular arachidonic acid levels block cell growth and induce apoptosis in HL-60 cells.

2 June 2018

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Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis

27 November 2018

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12 December 2020

Peroxisome proliferators induce apoptosis and decrease DNA synthesis in hepatoma cell lines

1 reference

12 December 2020

Evidence for peroxisome proliferator-activated receptor (PPAR)alpha-independent peroxisome proliferation: effects of PPARgamma/delta-specific agonists in PPARalpha-null mice

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In vivo behavior of murine epidermal cell lines derived from initiated and noninitiated skin

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12 December 2020

Lipid hydroperoxide-induced apoptosis: lack of inhibition by Bcl-2 over-expression

1 reference

12 December 2020

Selective inhibitors of 5-lipoxygenase reduce CML blast cell proliferation and induce limited differentiation and apoptosis

1 reference

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Ebselen inhibition of apoptosis by reduction of peroxides

1 reference

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An in vivo inhibitor of 5-lipoxygenase, MK886, at micromolar concentration induces apoptosis in U937 and CML cells

1 reference

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Arachidonic acid induces DNA-fragmentation in human polymorphonuclear neutrophil granulocytes

1 reference

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Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1 reference

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Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2

1 reference

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15-Deoxy-Delta(12,14)-prostaglandin J(2), a ligand for peroxisome proliferator-activated receptor-gamma, induces apoptosis in JEG3 choriocarcinoma cells

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