Ergolide, sesquiterpene lactone from Inula britannica, inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-kappaB (Q28366566)

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English	Ergolide, sesquiterpene lactone from Inula britannica, inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-kappaB	scientific article

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scholarly article

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Ergolide, sesquiterpene lactone from Inula britannica, inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-kappaB (English)

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ChEBI release 2020-05-28

sesquiterpene lactone

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Inula britannica

object named as

Inula britannica

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based on heuristic

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author name string

J Whan Han

1

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B Gon Lee

2

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Y Kee Kim

3

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J Woo Yoon

4

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H Kyoung Jin

5

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S Hong

6

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H Young Lee

7

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K Ro Lee

8

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H Woo Lee

9

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language of work or name

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publication date

June 2001

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British Journal of Pharmacology

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133

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4

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503-12

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NF-kappaB and AP-1 activation by nitric oxide attenuated apoptotic cell death in RAW 264.7 macrophages

1 reference

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20 March 2017

The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65

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20 March 2017

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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20 March 2017

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6 April 2017

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

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20 March 2017

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

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20 March 2017

Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2

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20 March 2017

I kappa B: a specific inhibitor of the NF-kappa B transcription factor

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20 March 2017

Nitric oxide: physiology, pathophysiology, and pharmacology

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20 March 2017

Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

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7 April 2017

Function and activation of NF-kappa B in the immune system

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7 April 2017

A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

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7 April 2017

Nitric oxide and macrophage function

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7 April 2017

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

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7 April 2017

NF-kappa B: ten years after

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7 April 2017

Prostaglandins and nitric oxide as molecular targets for anti-inflammatory therapy

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29 September 2017

Inhibition of NOS-2 expression in macrophages through the inactivation of NF-kappaB by andalusol.

1 reference

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29 September 2017

A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572810

29 September 2017

Inducible nitric oxide synthase: what difference does it make?

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29 September 2017

Upstream NF-kappaB site is required for the maximal expression of mouse inducible nitric oxide synthase gene in interferon-gamma plus lipopolysaccharide-induced RAW 264.7 macrophages

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29 September 2017

Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes

1 reference

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29 September 2017

Manipulation of distinct NFkappaB proteins alters interleukin-1beta-induced human rheumatoid synovial fibroblast prostaglandin E2 formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572810

29 September 2017

Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572810

29 September 2017

Role of nitric oxide in eicosanoid synthesis and uterine motility in estrogen-treated rat uteri

1 reference

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29 September 2017

Nitric oxide activates cyclooxygenase enzymes.

1 reference

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29 September 2017

Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta

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29 September 2017

Cross-talk between cyclooxygenase and nitric oxide pathways: prostaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin 1

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29 September 2017

Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation

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29 September 2017

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase

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29 September 2017

Signal transduction through NF-kappa B.

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2 June 2018

NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules.

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2 June 2018

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes

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2 June 2018

Cytotoxic sesquiterpene lactones from Inula britannica.

1 reference

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27 November 2018

Relationship between nitric oxide and prostaglandins in carrageenin pleurisy.

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27 November 2018

Inhibition of transcription factor NF-kappaB by sesquiterpene lactones: a proposed molecular mechanism of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/11399667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-1 beta induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/11399667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity and NMR spectral assignments of ergolide and bigelovin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11399667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide production by superficial and deep articular chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11399667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the expression of cyclooxygenase-2 by nitric oxide in rat peritoneal macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/11399667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2: an essential regulator of NO-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11399667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea

1 reference

https://pubmed.ncbi.nlm.nih.gov/11399667

12 December 2020

based on heuristic

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Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11399667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11399667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJP.0704099

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