Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs (Q28367095)

GOA release 2020-03-11

author name string

C J Foster

1

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D M Prosser

2

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J M Agans

3

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Y Zhai

4

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M D Smith

5

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J E Lachowicz

6

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F L Zhang

7

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E Gustafson

8

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F J Monsma

9

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M T Wiekowski

10

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S J Abbondanzo

11

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D N Cook

12

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M L Bayne

13

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S A Lira

14

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M S Chintala

Journal of Clinical Investigation

15

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language of work or name

English

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publication date

June 2001

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published in

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volume

107

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issue

12

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page(s)

1591-8

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cites work

Identification of the platelet ADP receptor targeted by antithrombotic drugs

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ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999

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Specific impairment of human platelet P2Y(AC) ADP receptor-mediated signaling by the antiplatelet drug clopidogrel

20 March 2017

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Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

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Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist

20 March 2017

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Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice

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Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation

29 September 2017

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P2Y1-receptors in human platelets which are pharmacologically distinct from P2Y(ADP)-receptors

29 September 2017

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Role of P2Y1 purinoceptor in ADP-induced platelet activation

29 September 2017

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Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets

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Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets

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The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells

29 September 2017

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Platelet aggregation monitored in a 96 well microplate reader is useful for evaluation of platelet agonists and antagonists

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ADP is not an agonist at P2X(1) receptors: evidence for separate receptors stimulated by ATP and ADP on human platelets

29 September 2017

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Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregates

2 June 2018

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Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice.

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Ligand specificity and ticlopidine effects distinguish three human platelet ADP receptors

27 November 2018

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Desensitization of the platelet aggregation response to ADP: differential down-regulation of the P2Y1 and P2cyc receptors

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12 December 2020

ADP receptors on platelets

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12 December 2020

Activation of ADP receptors and platelet function

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12 December 2020

Presence of P2X1 purinoceptors in human platelets and megakaryoblastic cell lines

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12 December 2020

The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel

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12 December 2020

Secreted ADP plays a central role in thrombin-induced phospholipase D activation in human platelets

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12 December 2020

Evidence for two distinct G-protein-coupled ADP receptors mediating platelet activation

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12 December 2020

A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase

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12 December 2020