Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species (Q28367213)

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English	Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species	scientific article

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scholarly article

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Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species (English)

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author name string

M A Lafleur

1

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M D Hollenberg

2

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S J Atkinson

3

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V Knäuper

4

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G Murphy

5

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D R Edwards

6

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language of work or name

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publication date

1 July 2001

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Biochemical Journal

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357

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Pt 1

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107-15

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Thrombin induces endothelial cell growth via both a proteolytic and a non-proteolytic pathway

1 reference

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Furin-independent pathway of membrane type 1-matrix metalloproteinase activation in rabbit dermal fibroblasts.

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Activation of MMP-2 by human GCT23 giant cell tumour cells induced by osteopontin, bone sialoprotein and GRGDSP peptides is RGD and cell shape change dependent.

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Thrombin promotes angiogenesis by a mechanism independent of fibrin formation

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Distinct receptors and signaling pathways in alpha-thrombin- and thrombin receptor peptide-induced vascular contractions

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Monitoring mRNA expression by polymerase chain reaction: the "primer-dropping" method

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Thrombin induces the activation of progelatinase A in vascular endothelial cells. Physiologic regulation of angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11415441

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based on heuristic

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Plasma membrane-dependent activation of gelatinase A in human vascular endothelial cells

1 reference

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Activation of human umbilical vein endothelial cell progelatinase A by phorbol myristate acetate: a protein kinase C-dependent mechanism involving a membrane-type matrix metalloproteinase

1 reference

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Thrombin promotes activation of matrix metalloproteinase-2 produced by cultured vascular smooth muscle cells

1 reference

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Involvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activation

1 reference

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Release of gelatinase A during platelet activation mediates aggregation

1 reference

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Thrombin promotes endothelial cell alignment in Matrigel in vitro and angiogenesis in vivo

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Vascular endothelial growth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: conversion of prothrombin to thrombin results in progelatinase A activation and cell proliferation

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Protein tyrosine phosphorylation in signalling pathways leading to the activation of gelatinase A: activation of gelatinase A by treatment with the protein tyrosine phosphatase inhibitor sodium orthovanadate

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1 reference

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Thrombin rapidly and efficiently activates gelatinase A in human microvascular endothelial cells via a mechanism independent of active MT1 matrix metalloproteinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11415441

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based on heuristic

inferred from PubMed ID database lookup

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