6-Thioguanine in children with acute lymphoblastic leukaemia: influence of food on parent drug pharmacokinetics and 6-thioguanine nucleotide concentrations (Q28367546)

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English	6-Thioguanine in children with acute lymphoblastic leukaemia: influence of food on parent drug pharmacokinetics and 6-thioguanine nucleotide concentrations	scientific article

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scholarly article

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6-Thioguanine in children with acute lymphoblastic leukaemia: influence of food on parent drug pharmacokinetics and 6-thioguanine nucleotide concentrations (English)

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pharmacokinetics

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based on heuristic

inferred from title

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based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

D L Lancaster

1

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N Patel

2

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L Lennard

3

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J S Lilleyman

4

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language of work or name

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publication date

June 2001

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British Journal of Clinical Pharmacology

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51

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531-9

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6

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Thiopurine methyltransferase deficiency in childhood lymphoblastic leukaemia: 6-mercaptopurine dosage strategies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014483

29 September 2017

Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014483

29 September 2017

Intracellular metabolites of mercaptopurine in children with lymphoblastic leukaemia: a possible indicator of non-compliance?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014483

29 September 2017

Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014483

29 September 2017

Can food influence the absorption of methotrexate in children with acute lymphoblastic leukaemia?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014483

2 June 2018

Pharmacology of 6-thioguanine in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014483

2 June 2018

The effect of food on the oral administration of 6-mercaptopurine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014483

2 June 2018

Influence of food intake on bioavailability of oral 6-mercaptopurine in children with acute lymphoblastic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014483

2 June 2018

Oral mercaptopurine in childhood leukemia: influence of food intake on bioavailability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014483

2 June 2018

Variability of 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014483

2 June 2018

Intraindividual variation in 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute lymphoblastic leukaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014483

2 June 2018

On the Cellular Pharmacokinetics of 6-Thioguanine in Acute Myelogenous Leukemia.

1 reference

https://api.crossref.org/works/10.1046%2FJ.0306-5251.2001.01391.X

21 January 2018

Delayed cytotoxicity of 6-mercaptopurine is compatible with mitotic death caused by DNA damage due to incorporation of 6-thioguanine into DNA as 6-thioguanine nucleotide

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-dependent kinetics of orally administered 6-mercaptopurine in children with leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of oral 6-mercaptopurine: relationship between plasma levels and urine excretion of parent drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

6-mercaptopurine plasma levels in children with acute lymphoblastic leukemia: relation to relapse risk and myelotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Milk could decrease the bioavailability of 6-mercaptopurine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maintenance chemotherapy for childhood acute lymphoblastic leukaemia: better in the evening

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral 6-mercaptopurine in childhood leukemia: parent drug pharmacokinetics and active metabolite concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of methotrexate on the bioavailability of oral 6-mercaptopurine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine and 6-thioguanine, in human red blood cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered?

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacology of oral thioguanine in acute myelogenous leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purine substrates for human thiopurine methyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circadian time-dependent response of childhood lymphoblastic leukemia to chemotherapy: a long-term follow-up study of survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving 6-thioguanine versus 6-mercaptopurine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11422012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1046/J.0306-5251.2001.01391.X

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