Efficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthase (Q28368221)

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Modular organization of genes required for complex polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Correlation of the avermectin polyketide synthase genes to the avermectin structure. Implications for designing novel avermectins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Generation of polyketide libraries via combinatorial biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Combinatorial approaches to polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Construction of new vectors for high-level expression in actinomycetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Evidence for a double-helical structure for modular polyketide synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Origin of starter units for erythromycin biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Tolerance and specificity of polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

The Molecular Basis of Celmer's Rules: The Stereochemistry of the Condensation Step in Chain Extension on the Erythromycin Polyketide Synthase†

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Combinatorial biosynthesis of erythromycin and complex polyketides

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Polyketide synthesis in vitro on a modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Molecular basis of celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

6-deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Erythromycin biosynthesis: exploiting the catalytic versatility of the modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Catalytic self-acylation of type II polyketide synthase acyl carrier proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Stereospecific acyl transfers on the erythromycin-producing polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

The loading domain of the erythromycin polyketide synthase is not essential for erythromycin biosynthesis in Saccharopolyspora erythraea

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

The thioesterase of the erythromycin-producing polyketide synthase: mechanistic studies in vitro to investigate its mode of action and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X

The Thioesterase of the Erythromycin-Producing Polyketide Synthase: Influence of Acyl Chain Structure on the Mode of Release of Substrate Analogues from the Acyl Enzyme Intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01025.X