Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil (Q28368896)

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English	Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil	scientific article

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scholarly article

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Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil (English)

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author name string

W Löscher

1

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D Hönack

2

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language of work or name

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publication date

December 1994

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British Journal of Pharmacology

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113

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4

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1349-57

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The excitatory amino acid antagonist D-CPP-ene (SDZ EAA-494) in patients with epilepsy

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Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines

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Differential pharmacological effects of benzodiazepine receptor inverse agonists

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Anticonvulsant efficacy of clonazepam and the beta-carboline ZK 93423 during chronic treatment in amygdala-kindled rats

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Anticonvulsant drugs: mechanisms of action

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29 September 2017

The behavioral pharmacology of NMDA receptor antagonists

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The NMDA receptor, NMDA antagonists and epilepsy therapy. A status report

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The depressant effect of GYKI 52466 on spinal reflex transmission in rats is mediated via non-NMDA and benzodiazepine receptors.

1 reference

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GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses

1 reference

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Is the muscle relaxant effect of diazepam in spastic mutant rats mediated through GABA-independent benzodiazepine receptors?

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Benzodiazepine antagonist Ro 15-1788: Neurological and behavioral effects

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Evaluation of CPP, a selective NMDA antagonist, in various rodent models of epilepsy. Comparison with other NMDA antagonists, and with diazepam and phenobarbital.

1 reference

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Mechanisms of action of anticonvulsant drugs

1 reference

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Electrophysiological studies with a 2,3-benzodiazepine muscle relaxant: GYKI 52466.

1 reference

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2 June 2018

The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II. Maximal electroshock seizure models

1 reference

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Is GABA release modulated by presynaptic excitatory amino acid receptors?

1 reference

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Differential effects of the excitatory amino acid antagonists, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 3-((+-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), on spinal reflex activity in mice.

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Pharmacological properties of the N-methyl-D-aspartate receptor system coupled to the evoked release of gamma-[3H] aminobutyric acid from striatal neurons in primary culture

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Comparison of binding at strychnine-sensitive (inhibitory glycine receptor) and strychnine-insensitive (N-methyl-D-aspartate receptor) glycine binding sites

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Effect of the benzodiazepine receptor antagonist Ro 15-1788 on the anticonvulsant and anticonflict actions of MK-801.

1 reference

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The effect of the non-NMDA receptor antagonist GYKI 52466 and NBQX and the competitive NMDA receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizures

1 reference

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Reversal of the anticonvulsant effects of diazepam on amygdaloid-kindled seizures by a specific benzodiazepine antagonist: RO 15-1788.

1 reference

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Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?

1 reference

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2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline enhances the protective activity of common antiepileptic drugs against maximal electroshock-induced seizures in mice.

1 reference

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A benzodiazepine recognition site associated with the non-NMDA glutamate receptor

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NMDA receptor antagonists decrease GABA outflow from the septum and increase acetylcholine outflow from the hippocampus: a microdialysis study.

1 reference

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Selective antagonists of benzodiazepines

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Chemical protection against ionizing radiation. I. Sampling methods for screening compounds in radiation protection studies with mice

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Excitatory amino acid-evoked release of gamma-[3H]aminobutyric acid from striatal neurons in primary culture

1 reference

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Anticonvulsant and behavioral effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine

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The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models

1 reference

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The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice

1 reference

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12 December 2020

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The non-N-methyl-D-aspartate receptor antagonists, GYKI 52466 and NBQX are anticonvulsant in two animal models of reflex epilepsy

1 reference

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Probenecid pretreatment enhances anticonvulsant action of NBQX in mice

1 reference

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12 December 2020

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Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models

1 reference

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12 December 2020

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Low doses of NMDA receptor antagonists synergistically increase the anticonvulsant effect of the AMPA receptor antagonist NBQX in the kindling model of epilepsy

1 reference

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Many agents that antagonize the NMDA receptor-channel complex in vivo also cause disturbances of motor coordination

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Relationship between GABA concentrations in cerebrospinal fluid and seizure excitability

1 reference

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inferred from PubMed ID database lookup

Identifiers

10.1111/J.1476-5381.1994.TB17146.X

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