Analysis of interleukin 12 protein production and mRNA expression in mice exposed topically to chemical allergens (Q28373375)

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R J Dearman

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D A Basketter

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I Kimber

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language of work or name

English

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publication date

1 January 1999

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number of pages

10

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Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ

inferred from page(s)

published in

Toxicology

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volume

132

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issue

1

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page(s)

57-66

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cites work

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Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

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Characterization of chemical allergens as a function of divergent cytokine secretion profiles induced in mice

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Contribution of CD4+ and CD8+ T lymphocyte subsets to the cytokine secretion patterns induced in mice during sensitization to contact and respiratory chemical allergens

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Classification of chemical allergens according to cytokine secretion profiles of murine lymph node cells

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Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist

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Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression

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Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells.

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Negative feedback mechanism suppresses interleukin-12 production by antigen-presenting cells interacting with T helper 2 cells

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Immune regulation: a new role for the CD8+ T cell

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Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

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Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent

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IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

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Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

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Quantitation of cytokine mRNA levels utilizing the reverse transcriptase-polymerase chain reaction following primary antigen-specific sensitization in vivo—I. Verification of linearity, reproducibility and specificity

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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

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Identification and induction of human keratinocyte-derived IL-12

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Cloning of a new cytokine that induces IFN-gamma production by T cells

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A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

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Selective expression of an interleukin-12 receptor component by human T helper 1 cells

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Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines.

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Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

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Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4

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Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes.

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Analysis of cytokine mRNA expression following repeated exposure of mice to chemical contact and respiratory allergens.

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