Synthesis and antiviral activity of acyclovir-5'-(phenyl methoxy alaninyl) phosphate as a possible membrane-soluble nucleotide prodrug (Q28376570)

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5 November 2019

title

Synthesis and antiviral activity of acyclovir-5'-(phenyl methoxy alaninyl) phosphate as a possible membrane-soluble nucleotide prodrug (English)

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5 November 2019

1

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5 November 2019

Sarah A Knaggs

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ORCID Public Data File 2021

author name string

M J Slater

2

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5 November 2019

N R Parry

3

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5 November 2019

A Perry

4

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5 November 2019

S Harris

5

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5 November 2019

language of work or name

English

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publication date

1 April 2000

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Bioorganic & Medicinal Chemistry Letters

5 November 2019

published in

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5 November 2019

volume

10

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5 November 2019

issue

7

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5 November 2019

page(s)

645-647

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5 November 2019

cites work

Successors to acyclovir

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Inhibition of DNA polymerase from herpes simplex virus-infected wi-38 cells by phosphonoacetic Acid.

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Foscarnet Therapy in Five Patients with AIDS and Acyclovir-resistant Varicella-Zoster Virus Infection

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7 January 2021

Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and multiple-dose administration to normal volunteers

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7 January 2021

Synthesis and anti-HIV activity of some haloalkyl phosphoramidate derivatives of 3'-azido-3'-deoxythymidine (AZT): potent activity of the trichloroethyl methoxyalaninyl compound

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7 January 2021

Phosphoramidate derivatives of d4T with improved anti-HIV efficacy retain full activity in thymidine kinase-deficient cells

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7 January 2021

Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.

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7 January 2021

Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives

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7 January 2021

Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine

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7 January 2021

Synthesis and anti-herpes virus activity of 2'-deoxy-4'-thiopyrimidine nucleosides

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7 January 2021

Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.

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7 January 2021

Phosphoramidate derivatives of 2′,3′-didehydro-2′,3′-dideoxyadenosine [d4A] have markedly improved anti-HIV potency and selectivity

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7 January 2021

Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency

1 reference

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7 January 2021

10.1016/S0960-894X(00)00061-5

Identifiers

DOI

1 reference

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5 November 2019

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