G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action (Q28376789)

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W R Wilson

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R D Mayfield

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S J Brozowski

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R A Morrisett

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R A Harris

Neuronal sodium and potassium channels: structure and function

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language of work or name

English

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publication date

December 1999

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published in

Nature Neuroscience

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volume

2

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issue

12

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page(s)

1084-90

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cites work

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Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia.

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Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation

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Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels

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Identification of domains conferring G protein regulation on inward rectifier potassium channels

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Evidence that direct binding of Gβγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation

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G beta gamma directly binds to the carboxyl terminus of the G protein-gated muscarinic K+ channel, GIRK1.

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A region of the muscarinic-gated atrial K+ channel critical for activation by G protein beta gamma subunits.

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New roles for RGS2, 5 and 8 on the ratio-dependent modulation of recombinant GIRK channels expressed in Xenopus oocytes

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Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma

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Activation of the atrial KACh channel by the betagamma subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates

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G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons

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Agonist-induced desensitization of the mu opioid receptor-coupled potassium channel (GIRK1).

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The role of protein kinase C in cellular tolerance to ethanol

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Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?

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Alcohol action on a neuronal membrane receptor: evidence for a direct interaction with the receptor protein

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Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy

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Actions of long chain alcohols on GABAA and glutamate receptors: relation to in vivo effects

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Enhancement of homomeric glycine receptor function by long-chain alcohols and anaesthetics

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Inhalational anesthetics activate two-pore-domain background K+ channels

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Identification of functional domains of adenylyl cyclase using in vivo chimeras

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7 January 2021

G beta gamma binds directly to the G protein-gated K+ channel, IKACh

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7 January 2021

G-protein-gated inward rectifier K+ channel proteins (GIRK1) are present in the soma and dendrites as well as in nerve terminals of specific neurons in the brain.

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7 January 2021

Calcium-dependent chloride currents elicited by injection of ethanol into Xenopus oocytes

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7 January 2021

Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes.

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7 January 2021

Substrate specificity of alcohol dehydrogenases

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7 January 2021

IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brain

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7 January 2021

Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants.

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7 January 2021