Lovastatin-induced apoptosis of human medulloblastoma cell lines in vitro (Q28377506)

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8 December 2019

title

Lovastatin-induced apoptosis of human medulloblastoma cell lines in vitro (English)

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8 December 2019

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R J Macaulay

1

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8 December 2019

W Wang

2

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8 December 2019

J Dimitroulakos

3

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8 December 2019

L E Becker

4

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8 December 2019

H Yeger

5

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8 December 2019

language of work or name

English

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publication date

1 March 1999

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Journal of Neuro-Oncology

8 December 2019

published in

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8 December 2019

volume

42

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8 December 2019

issue

1

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8 December 2019

page(s)

1-11

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Regulation of the mevalonate pathway

8 December 2019

cites work

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Inhibition of proliferation and induction of differentiation in medulloblastoma- and astrocytoma-derived cell lines with phenylacetate

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Accumulation of lovastatin, but not pravastatin, in the blood of cyclosporine-treated kidney graft patients after multiple doses

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Surveillance scanning of children with medulloblastoma.

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Concentrations of pravastatin and lovastatin in cerebrospinal fluid in healthy subjects.

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Regulation of proliferation and Ras localization in transformed cells by products of mevalonate metabolism

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Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis

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Lovastatin induces growth inhibition and apoptosis in human malignant glioma cells

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Tumor resistance to oxidative stress: association with ras oncogene expression and reversal by lovastatin, an inhibitor of p21ras isoprenylation

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Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med.

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Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.

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Phenotypic analysis of four human medulloblastoma cell lines and transplantable xenografts

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Lipid metabolism as a target for brain cancer therapy: synergistic activity of lovastatin and sodium phenylacetate against human glioma cells.

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Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.

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Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

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Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts

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Improved survival with the use of adjuvant chemotherapy in the treatment of medulloblastoma

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Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note

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Requirement for mevalonate in cycling cells: quantitative and temporal aspects

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Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

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Geranylgeraniol restores cell proliferation to lovastatin treated C6 glial cells.

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The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

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Programmed cell death in an estrogen-independent human breast cancer cell line, MDA-MB-468

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Establishment and characterization of four human medulloblastoma-derived cell lines

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12 December 2020

Characterization of five new cell lines derived from human primitive neuroectodermal tumors of the central nervous system.

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12 December 2020

Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors

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Characterization of the human cell line TE671.

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Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma

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12 December 2020

Multidrug resistance gene expression in pediatric primitive neuroectodermal tumors of the central nervous system

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12 December 2020

Treatment of standard risk medulloblastoma with craniospinal irradiation, carboplatin, and vincristine.

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12 December 2020

The N-ras oncogene is activated in a human medulloblastoma cell line

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12 December 2020

O6-alkylguanine DNA-alkyltransferase is not a major determinant of sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea in four medulloblastoma cell lines

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12 December 2020

Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid

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12 December 2020

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

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12 December 2020

Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU, and vincristine chemotherapy.

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12 December 2020

Effects of basic fibroblast growth factor on the differentiation, growth, and viability of a new human medulloblastoma cell line (UM-MB1).

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Expanded clinical evaluation of lovastatin (EXCEL) study results: IV. Additional perspectives on the tolerability of lovastatin

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Ototoxic effect of cisplatin in children with brain tumors

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12 December 2020

Methylazoxymethanol acetate-induced apoptosis in the external granule cell layer of the developing cerebellum of the rat is associated with strong c-Jun expression and formation of high molecular weight c-Jun complexes

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12 December 2020

Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin

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12 December 2020

The mevalonate pathway: importance in mesangial cell biology and glomerular disease.

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12 December 2020

Quality of long-term survival in young children with medulloblastoma

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12 December 2020

Efficacy of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in the treatment of patients with hypercholesterolemia: a meta-analysis of clinical trials

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12 December 2020

Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors

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12 December 2020

Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc

1 reference

12 December 2020

Inhibition of pancreatic adenocarcinoma cell growth by lovastatin

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12 December 2020

Optimal detection of apoptosis by flow cytometry depends on cell morphology.

1 reference

12 December 2020

HMG-CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: lovastatin specifically targets P-glycoprotein-expressing cells

1 reference

12 December 2020