Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89 (Q28378905)

1

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W H Miller

2

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E P Garvey

3

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M H St Clair

4

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S M Daluge

5

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S S Good

Antimicrobial Agents and Chemotherapy

6

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language of work or name

English

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publication date

May 1997

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published in

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volume

41

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issue

5

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page(s)

1099-107

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cites work

Combination of mutations in human immunodeficiency virus type 1 reverse transcriptase required for resistance to the carbocyclic nucleoside 1592U89

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1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity

20 March 2017

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5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile

20 March 2017

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Mode of action of (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine against herpesviruses

20 March 2017

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Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

20 March 2017

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Resolution of racemic carbovir and selective inhibition of human immunodeficiency virus by the (-) enantiomer

20 March 2017

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Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells

20 March 2017

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20 March 2017

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Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity

20 March 2017

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DNA chain termination activity and inhibition of human immunodeficiency virus reverse transcriptase by carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine triphosphate

20 March 2017

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The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

20 March 2017

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Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells

20 March 2017

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A novel human phosphotransferase highly specific for adenosine

20 March 2017

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

20 March 2017

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Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives

7 April 2017

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Mechanisms of action of mycophenolic acid

29 September 2017

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Metabolism of carbovir, a potent inhibitor of human immunodeficiency virus type 1, and its effects on cellular metabolism

29 September 2017

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Inhibitors of adenosine deaminase

29 September 2017

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Spectrum of antiviral activity and mechanism of action of zidovudine. An overview

29 September 2017

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Potent and selective activity of a new carbocyclic nucleoside analog (carbovir: NSC 614846) against human immunodeficiency virus in vitro

29 September 2017

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Targeted therapy of human immunodeficiency virus‐related disease

29 September 2017

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Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine

29 September 2017

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Altered kinetics of AMP deaminase by myosin binding

29 September 2017

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HIV inhibitors targeted at the reverse transcriptase

29 September 2017

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Adenosine kinase from rabbit liver. I. Purification by affinity chromatography and properties

29 September 2017

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Effects of acyclovir and its metabolites on purine nucleoside phosphorylase.

29 September 2017

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Subcellular fractionation of rat liver.

2 June 2018

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Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro

2 June 2018

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Metabolism of the carbocyclic nucleoside analogue carbovir, an inhibitor of human immunodeficiency virus, in human lymphoid cells

2 June 2018

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Modulation of Metabolism and Anti-HIV-1 Activity of Purine 2′,3′-Dideoxynucleosides by IMP Dehydrogenase Inhibitors

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=163857

Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases

2 June 2018

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Adenylate deaminase: Potent inhibition by 2′-deoxycoformycin 5′-phosphate

27 November 2018

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12 December 2020

The metabolism of 2'-deoxycoformycin by L1210 cells invitro

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12 December 2020

Adenosine deaminase and adenylate deaminase: comparative kinetic studies with transition state and ground state analogue inhibitors

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12 December 2020

Conversion of 2,6-diamino-9-(2-hydroxyethoxymethyl)purine to acyclovir as catalyzed by adenosine deaminase

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12 December 2020

In vitro metabolism of deoxycoformycin in human T lymphoblastoid cells. Phosphorylation of deoxycoformycin and incorporation into cellular DNA

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12 December 2020

The pharmacokinetics of (-)-carbovir in rats. Evidence for nonlinear elimination

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12 December 2020

The bioavailability and nonlinear clearance of (-)-carbovir in the rat

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12 December 2020

Enantiomeric selectivity of carbovir transport

1 reference

12 December 2020