Characterization of anti-Toxoplasma activity of SDZ 215-918, a cyclosporin derivative lacking immunosuppressive and peptidyl-prolyl-isomerase-inhibiting activity: possible role of a P glycoprotein in Toxoplasma physiology (Q28379120)

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English	Characterization of anti-Toxoplasma activity of SDZ 215-918, a cyclosporin derivative lacking immunosuppressive and peptidyl-prolyl-isomerase-inhibiting activity: possible role of a P glycoprotein in Toxoplasma physiology	scientific article

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scholarly article

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Characterization of anti-Toxoplasma activity of SDZ 215-918, a cyclosporin derivative lacking immunosuppressive and peptidyl-prolyl-isomerase-inhibiting activity: possible role of a P glycoprotein in Toxoplasma physiology (English)

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author name string

J A Silverman

1

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M L Hayes

2

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B J Luft

3

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K A Joiner

4

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language of work or name

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publication date

September 1997

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Antimicrobial Agents and Chemotherapy

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41

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9

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1859-66

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MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

20 March 2017

P-glycoproteins and multidrug resistance

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

20 March 2017

In vitro effects of artemisinin ether, cycloguanil hydrochloride (alone and in combination with sulfadiazine), quinine sulfate, mefloquine, primaquine phosphate, trifluoperazine hydrochloride, and verapamil on Toxoplasma gondii

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

20 March 2017

Phosphatidylcholine translocase: a physiological role for the mdr2 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

20 March 2017

Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

20 March 2017

Clinical trials of P-glycoprotein reversal in solid tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

P-glycoprotein--a mediator of multidrug resistance in tumour cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Leishmania amazonensis: multidrug resistance in vinblastine-resistant promastigotes is associated with rhodamine 123 efflux, DNA amplification, and RNA overexpression of a Leishmania mdr1 gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

A soluble secretory protein of the intracellular parasite Toxoplasma gondii associates with the parasitophorous vacuole membrane through hydrophobic interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Isolation, cDNA sequences, and biochemical characterization of the major cyclosporin-binding proteins of Toxoplasma gondii

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii. Implications for the target of macrolide antibiotics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Cyclosporin A, FK506 and rapamycin: more than just immunosuppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Multidrug resistance and P-glycoproteins in parasitic protozoa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Multidrug resistance and the role of P-glycoprotein knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

The antimicrobial activities of cyclosporine, FK506, and rapamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Effect of clindamycin on intracellular replication, protein synthesis, and infectivity of Toxoplasma gondii

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Inhibition by cyclosporin A of rodent malaria in vivo and human malaria in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

New micromethod to study the effect of antimicrobial agents on Toxoplasma gondii: comparison of sulfadoxine and sulfadiazine individually and in combination with pyrimethamine and study of clindamycin, metronidazole, and cyclosporin A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Metabolism of cyclosporine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Parasiticidal effect of clindamycin on Toxoplasma gondii grown in cultured cells and selection of a drug-resistant mutant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Immunophilin-sensitive protein phosphatase action in cell signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Cyclosporins as drug resistance modifiers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Immunity, microbial pathogenesis, and immunophilins: finding the keys, now where are the locks?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Effect of cytochalasin D on Toxoplasma gondii cell entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Specific Labeling of IntracellularToxoplasma gondiiwith Uracil*

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

29 September 2017

Insertional tagging, cloning, and expression of the Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyltransferase gene. Use as a selectable marker for stable transformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

2 June 2018

Chemistry of the natural cyclosporin metabolites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

2 June 2018

Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

2 June 2018

Reciprocal correlation between expression of P-glycoprotein and accumulation of rhodamine 123 in human tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

2 June 2018

Monoclonal antibody JSB-1 detects a highly conserved epitope on the P-glycoprotein associated with multi-drug-resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

2 June 2018

Synthesis, conformation, and immunosuppressive activities of three analogues of cyclosporin A modified in the 1-position

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

2 June 2018

Plasmodium falciparum: ATP/ADP transport across the parasitophorous vacuolar and plasma membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

2 June 2018

Toxoplasma gondii: fusion competence of parasitophorous vacuoles in Fc receptor-transfected fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

2 June 2018

Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

2 June 2018

Invasion of Toxoplasma gondii occurs by active penetration of the host cell.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

27 November 2018

Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164025

27 November 2018

Cyclosporine and analogues: structural requirements for immunosuppressive activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9303374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surface antigens of Toxoplasma gondii

1 reference

https://pubmed.ncbi.nlm.nih.gov/9303374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A enhances elimination of intracellular L. major parasites by murine macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/9303374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of extracellular ions on motility and cell entry in Toxoplasma gondii

1 reference

https://pubmed.ncbi.nlm.nih.gov/9303374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential inhibition by cyclosporins of primary-active ATP-dependent transporters in the hepatocyte canalicular membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/9303374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxoplasma gondii: membrane properties of active energy-dependent invasion of host cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9303374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin partitions into phospholipid vesicles and disrupts membrane architecture

1 reference

https://pubmed.ncbi.nlm.nih.gov/9303374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of cyclosporine on Toxoplasma gondii in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9303374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Derivatives of a Novel Cyclopeptolide. 2. Synthesis, Activity against Multidrug Resistance in CHO and KB Cells in vitro, and Structure-Activity Relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/9303374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attachment of Toxoplasma gondii to host cells involves major surface protein, SAG-1 (P30)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9303374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxoplasma gondii tachyzoites possess an unusual plasma membrane adenosine transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/9303374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of etoposide with SDZ PSC 833 as a modulator of multidrug resistance in patients with cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/9303374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.41.9.1859

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