Human PON1, a biomarker of risk of disease and exposure (Q28386131)

Europe PubMed Central

title

Human PON1, a biomarker of risk of disease and exposure (English)

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13

C P Zabetian

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author name string

C E Furlong

1

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S M Suzuki

2

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R C Stevens

3

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J Marsillach

4

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R J Richter

5

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G P Jarvik

6

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H Checkoway

7

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A Samii

8

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L G Costa

9

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A Griffith

10

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J W Roberts

11

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D Yearout

Chemico-biological Interactions

12

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language of work or name

English

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publication date

6 September 2010

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published in

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volume

187

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page(s)

355-61

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issue

1-3

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cites work

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Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism

20 March 2017

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The paraoxonase gene family and atherosclerosis

20 March 2017

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Genetic and environmental factors modulating serum concentrations and activities of the antioxidant enzyme paraoxonase-1

20 March 2017

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The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis

20 March 2017

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Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression

20 March 2017

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No association between paraoxonase 1 (PON1) gene polymorphisms and susceptibility to Parkinson's disease in a Chinese population

20 March 2017

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Human serum Paraoxonase/Arylesterase's retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids : apolipoprotein A-I stabilizes activity

20 March 2017

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The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin

20 March 2017

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Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence

20 March 2017

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Engineering human PON1 in an E. coli expression system

20 March 2017

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Determination of paraoxonase 1 status without the use of toxic organophosphate substrates

29 September 2017

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The roles of PON1 and PON2 in cardiovascular disease and innate immunity

29 September 2017

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Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds

29 September 2017

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The paraoxonases: role in human diseases and methodological difficulties in measurement.

29 September 2017

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Paraoxonase 1 (PON1) status and substrate hydrolysis

29 September 2017

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Genetic models of Parkinson disease

29 September 2017

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Macrophage paraoxonase 1 (PON1) binding sites

29 September 2017

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Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning

29 September 2017

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Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1.

29 September 2017

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Genetics of Parkinson disease

29 September 2017

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A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases

29 September 2017

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Stoichiometric and catalytic scavengers as protection against nerve agent toxicity: a mini review

29 September 2017

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The role of paraoxonase 1 activity in cardiovascular disease: potential for therapeutic intervention

29 September 2017

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Paraoxonase gene polymorphisms, oxidative stress, and diseases

29 September 2017

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Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes.

29 September 2017

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Paraoxon hydrolysis in human serum mediated by a genetically variable arylesterase and albumin

29 September 2017

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The human serum paraoxonase/arylesterase polymorphism.

29 September 2017

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Paraoxonase-1 promoter haplotypes and serum paraoxonase: a predominant role for polymorphic position - 107, implicating the Sp1 transcription factor

29 September 2017

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Immunohistochemical evidence for the expression and induction of paraoxonase in rat liver, kidney, lung and brain tissue. Implications for its physiological role

2 June 2018

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Perinatal development of human blood esterases

2 June 2018

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Determination of paraoxonase 1 status and genotypes at specific polymorphic sites.

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Expression and activity of paraoxonase 1 in human cataractous lens tissue.

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Immunohistochemical analysis of paraoxonases-1, 2, and 3 expression in normal mouse tissues

27 November 2018

1 reference

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Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Pesticides exposure and genetic polymorphism of paraoxonase in the susceptibility of Parkinson's disease.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Paraoxonase 1 (PON1) gene polymorphisms and Parkinson's disease in a Finnish population

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Expression of human paraoxonase (PON1) during development.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Novel paraoxonase (PON1) nonsense and missense mutations predicted by functional genomic assay of PON1 status

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Paraoxonase 1 promoter and coding region polymorphisms in Parkinson's disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Association between human paraoxonase gene polymorphism and chronic symptoms in pesticide-exposed workers

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Paraoxonase and susceptibility to organophosphorus poisoning in farmers dipping sheep

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Further evidence for an association of the paraoxonase 1 (PON1) Met-54 allele with Parkinson's disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Paraoxonase (PON1) polymorphisms in farmers attributing ill health to sheep dip.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Paraoxonase status in coronary heart disease: are activity and concentration more important than genotype?

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Determination of paraoxonase (PON1) status requires more than genotyping.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Genetic polymorphism of paraoxonase 1 (PON1) and susceptibility to Parkinson's disease.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Phosphotriesterase decreases paraoxon toxicity in mice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

The molecular basis of the human serum paraoxonase activity polymorphism.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Serum paraoxonase status: a major factor in determining resistance to organophosphates.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Spectrophotometric assays for the enzymatic hydrolysis of the active metabolites of chlorpyrifos and parathion by plasma paraoxonase/arylesterase.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Serum paraoxonase and its influence on paraoxon and chlorpyrifos-oxon toxicity in rats

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035622

Future studies of low-activity PON1 phenotype subjects may reveal how PON1 protects against cardiovascular disease

27 November 2018

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12 December 2020

Utilization of copper as a paramagnetic probe for the binuclear metal center of phosphotriesterase

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12 December 2020

Association of paraoxonase-1 activity and concentration with angiographic severity and extent of coronary artery disease

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12 December 2020

A polymorphism upstream from the human paraoxonase (PON1) gene and its association with PON1 expression

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12 December 2020

Increased immunolocalization of paraoxonase, clusterin, and apolipoprotein A-I in the human artery wall with the progression of atherosclerosis

1 reference

12 December 2020

Promoter polymorphisms of human paraoxonase PON1 gene and serum paraoxonase activities and concentrations

1 reference

12 December 2020

Enzymatically Active Paraoxonase-1 Is Located at the External Membrane of Producing Cells and Released by a High Affinity, Saturable, Desorption Mechanism

1 reference

12 December 2020

AGE VARIATION IN PLASMA ARYLESTERASE ACTIVITY IN CHILDREN

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12 December 2020

[Polymorphisms in the genes of cytochrome oxidase P450 2D6 (CYP2D6), paraoxonase 1 (PON1) and apolipoprotein E (APOE) as risk factors for Parkinson's disease]

1 reference

12 December 2020

Paraoxonase 1 Met--Leu 54 polymorphism is associated with Parkinson's disease

1 reference

12 December 2020

Paraoxonase and arylesterase activities in coronary artery disease

1 reference

12 December 2020

Paraoxonase and coronary heart disease risk: language misleads, linkage misinforms, function clarifies

1 reference

12 December 2020

The role of A-esterase in the acute toxicity of paraoxon, TEPP, and parathion

1 reference

12 December 2020

Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease

1 reference

12 December 2020

Identification of a distinct human high-density lipoprotein subspecies defined by a lipoprotein-associated protein, K-45. Identity of K-45 with paraoxonase

1 reference

12 December 2020