Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer (Q28388006)

negative regulation of gene expression, epigenetic

GOA release 2020-03-11

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GOA release 2020-03-11

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64

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Alan Ashworth

60

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Richard Houlston

50

Richard Houlston

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Tsun-Po Yang

Tsun-Po Yang

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Julian Weldon Adlard

Julian W Adlard

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Peter Humburg

Peter Humburg

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Neil M Walker

Neil M Walker

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Matthew A. Brown

Matthew A Brown

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Christopher J Lord

Christopher J Lord

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Gareth Evans

D Gareth Evans

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Diana Eccles

Diana Eccles

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Jorge Reis-Filho

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Jorge S Reis-Filho

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Peter Donnelly

Peter Donnelly

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Mark McCarthy

Mark I McCarthy

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Clare Turnbull

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Clare Turnbull

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John A. Todd

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John A Todd

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Antonis C Antoniou

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Antonis C Antoniou

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Elise Ruark

1

Elise Ruark

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Anthony Renwick

8

Anthony Renwick

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Alexander J Mentzer

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Rosalind Eeles

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ORCID Public Data File 2021

Naser Ansari-Pour

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Wellcome Trust Case Control Consortium

Naser Ansari Pour

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57

Wellcome Trust Case Control Consortium

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Rachel Brough

6

Rachel Brough

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Ilirjana Bajrami

5

Ilirjana Bajrami

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Chey Loveday

4

Chey Loveday

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Emma Ramsay

10

Emma Ramsay

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Margaret Warren-Perry

13

Margaret Warren-Perry

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Katie Snape

2

Katie Snape

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Julian Barwell

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Julian Barwell

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Glen Brice

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Glen Brice

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Jackie Cook

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Jackie Cook

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Rosemarie Davidson

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Rosemarie Davidson

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Lynn Greenhalgh

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Lynn Greenhalgh

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Alex Henderson

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Alex Henderson

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Louise Izatt

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Louise Izatt

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Fiona Lalloo

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Fiona Lalloo

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Zosia Miedzybrodzka

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Zosia Miedzybrodzka

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Joan Paterson

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Joan Paterson

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Susan Shanley

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Susan Shanley

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Sheila Seal

9

Sheila Seal

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Daniel Nava Rodrigues

7

Daniel Nava Rodrigues

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Martin Göring

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Martin Gore

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author name string

Silvana Del Vecchio Duarte

11

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Manuel A Rivas

12

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Anna Zachariou

14

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Adriana Campion-Flora

15

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Sandra Hanks

16

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Anne Murray

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Jenny Douglas

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Lorna Gregory

20

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Andrew Rimmer

21

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Jonathan Berg

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Angela F Brady

27

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Carole Brewer

28

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Cyril Chapman

30

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Alan Donaldson

33

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Fiona Douglas

34

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Ajith Kumar

40

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Patrick J Morrison

43

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Mary Porteous

45

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Mark T Rogers

46

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Lisa Walker

48

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Mark J Caufield

52

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Panagiotis Deloukas

53

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The Breast and Ovarian Cancer Susceptibility Collaboration

Detectable clonal mosaicism and its relationship to aging and cancer

56

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language of work or name

English

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publication date

17 January 2013

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published in

Nature

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volume

493

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issue

7432

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page(s)

406-10

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cites work

1 reference

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Detectable clonal mosaicism from birth to old age and its relationship to cancer

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Germline mutations in RAD51D confer susceptibility to ovarian cancer

20 March 2017

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Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

20 March 2017

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Fast and accurate short read alignment with Burrows-Wheeler transform

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PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

20 March 2017

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Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

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Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification

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Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

20 March 2017

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Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

20 March 2017

1 reference

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Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

20 March 2017

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Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing

20 March 2017

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Predisposition gene identification in common cancers by exome sequencing: insights from familial breast cancer

7 April 2017

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Genomic and mutational profiling of ductal carcinomas in situ and matched adjacent invasive breast cancers reveals intra-tumour genetic heterogeneity and clonal selection

29 September 2017

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Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).

29 September 2017

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Preparation of next-generation sequencing libraries using Nextera™ technology: simultaneous DNA fragmentation and adaptor tagging by in vitro transposition

29 September 2017

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Uncovering the roles of rare variants in common disease through whole-genome sequencing

29 September 2017

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The inherited genetics of ovarian and endometrial cancer

29 September 2017

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Genome-wide association study identifies five new breast cancer susceptibility loci

29 September 2017

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Tiling path genomic profiling of grade 3 invasive ductal breast cancers

29 September 2017

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PPM1D is a potential therapeutic target in ovarian clear cell carcinomas

29 September 2017

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PPM1D430, a novel alternative splicing variant of the human PPM1D, can dephosphorylate p53 and exhibits specific tissue expression

29 September 2017

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Genetic predisposition to breast cancer: past, present, and future

29 September 2017

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The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

29 September 2017

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Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay

29 September 2017

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A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.

29 September 2017

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Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase

29 September 2017

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ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles

29 September 2017

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Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles

29 September 2017

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Crossref

https://api.crossref.org/works/10.1038%2FNATURE11725

Germline RAD51C mutations confer susceptibility to ovarian cancer

21 January 2018

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Crossref

https://api.crossref.org/works/10.1038%2FNATURE11725

Evaluation of association methods for analysing modifiers of disease risk in carriers of high-risk mutations.

21 January 2018

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Crossref

https://api.crossref.org/works/10.1038%2FNATURE11725

Evidence for further breast cancer susceptibility genes in addition to BRCA1 and BRCA2 in a population-based study

21 January 2018

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12 December 2020

Cancer incidence in five continents. Volume VIII

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12 December 2020

Polygenic inheritance of breast cancer: Implications for design of association studies

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12 December 2020

Programs for pedigree analysis: Mendel, Fisher, and dGene

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12 December 2020

Identifiers

DOI

10.1038/NATURE11725

1 reference

Dimensions Publication ID

2166192

1027522882

0 references

2166192

1 reference

1 reference

1 reference