Introducing the "TCDD-inducible AhR-Nrf2 gene battery" (Q28391047)

1

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Scott A Reisman

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Lauren M Aleksunes

3

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Curtis D Klaassen

4

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language of work or name

English

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publication date

October 2009

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published in

Toxicological Sciences

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Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries

volume

111

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issue

2

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page(s)

238-46

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cites work

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Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap n collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2)

20 March 2017

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Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

20 March 2017

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Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis

20 March 2017

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Antioxidant response element-mediated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induction of human NAD(P)H:quinone oxidoreductase 1 gene expression

20 March 2017

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An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

20 March 2017

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Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

20 March 2017

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Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16

20 March 2017

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Stimulation of in vivo hepatic uptake and in vitro hepatic binding of [125I]2-lodo-3,7,8-trichlorodibenzo-p-dioxin by the administration of agonist for the Ah receptor

20 March 2017

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A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

20 March 2017

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Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development

20 March 2017

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Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase

20 March 2017

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

20 March 2017

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NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

7 April 2017

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The aryl hydrocarbon receptor complex

7 April 2017

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2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

7 April 2017

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Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species

7 April 2017

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Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers

29 September 2017

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Molecular mechanisms of Nrf2-mediated antioxidant response

29 September 2017

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Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse

29 September 2017

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Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.

29 September 2017

1 reference

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TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone

29 September 2017

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Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor

29 September 2017

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Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742581

Regulation of NAD(P)H:quinone oxidoreductase 1 gene expression by CYP1A1 activity

29 September 2017

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Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction.

29 September 2017

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Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action

29 September 2017

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Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear fa

29 September 2017

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Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity

2 June 2018

1 reference

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Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse

2 June 2018

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Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery

2 June 2018

1 reference

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Binding of 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin to a common Ah receptor site in mouse and rat hepatic cytosols

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742581

Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of aryl hydrocarbon hydroxylase, with 3-methylcholanthrene.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742581

Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver

2 June 2018

1 reference

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Mechanism of rat UDP-glucuronosyltransferase 1A6 induction by oltipraz: evidence for a contribution of the Aryl hydrocarbon receptor pathway

2 June 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP115

Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP115

In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP115

Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP115

Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP115

Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP115

Differences in gene expression and benzo[a]pyrene-induced DNA adduct formation in the liver of three strains of female mice with identical AhRb2 genotype treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and/or benzo[a]pyrene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP115

Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742581

Correlation between toxicity and effects on intermediary metabolism in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated male C57BL/6J and DBA/2J mice

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/19474220

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dioxin causes a sustained oxidative stress response in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/19474220

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated hepatotoxicity in C57BL/6J and DBA/2J mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19474220

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/TOXSCI/KFP115

1 reference

309818

309818

1 reference

1 reference

1 reference