Mesenchymal stem cells modified with a single-chain antibody against EGFRvIII successfully inhibit the growth of human xenograft malignant glioma (Q28473229)

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English	Mesenchymal stem cells modified with a single-chain antibody against EGFRvIII successfully inhibit the growth of human xenograft malignant glioma	scientific article

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Mesenchymal stem cells modified with a single-chain antibody against EGFRvIII successfully inhibit the growth of human xenograft malignant glioma (English)

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Maciej S Lesniak

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Maciej S Lesniak

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author name string

Irina V Balyasnikova

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Sherise D Ferguson

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Sadhak Sengupta

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Yu Han

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publication date

18 March 2010

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5

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e9750

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3

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Creative Commons Attribution 4.0 International

18 March 2010

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April 2022 Public Data File from Crossref

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

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19 March 2017

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

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7 April 2017

Malignant astrocytic glioma: genetics, biology, and paths to treatment

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Neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies

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29 September 2017

Genetic modification of mesenchymal stem cells to express a single-chain antibody against EGFRvIII on the cell surface

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29 September 2017

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Growth inhibition of colorectal carcinoma by lentiviral TRAIL-transgenic human mesenchymal stem cells requires their substantial intratumoral presence.

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29 September 2017

The EGFRvIII variant in glioblastoma multiforme

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29 September 2017

Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma

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29 September 2017

Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells

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Bone marrow multipotent mesenchymal stroma cells act as pericyte-like migratory vehicles in experimental gliomas

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Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice.

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29 September 2017

Mesenchymal stem cells derived from human adipose tissues favor tumor cell growth in vivo

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29 September 2017

Monoclonal antibody cetuximab binds to and down-regulates constitutively activated epidermal growth factor receptor vIII on the cell surface.

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29 September 2017

Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

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29 September 2017

Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841188

29 September 2017

Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma

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29 September 2017

IkappaBalphaM suppresses angiogenesis and tumorigenesis promoted by a constitutively active mutant EGFR in human glioma cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841188

29 September 2017

Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841188

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Increased binding affinity enhances targeting of glioma xenografts by EGFRvIII-specific scFv

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125I-labeled anti-epidermal growth factor receptor-vIII single-chain Fv exhibits specific and high-level targeting of glioma xenografts.

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The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

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29 September 2017

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841188

29 September 2017

Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841188

29 September 2017

Structural alterations of the epidermal growth factor receptor gene in human gliomas

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29 September 2017

Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor.

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2 June 2018

Analysis of genomic rearrangements associated with EGRFvIII expression suggests involvement of Alu repeat elements

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2 June 2018

Suppression of metastasis formation by a recombinant single chain antibody-toxin targeted to full-length and oncogenic variant EGF receptors

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2 June 2018

Expression of epidermal growth factor receptors in human brain tumors

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2 June 2018

Determination of subcutaneous tumor size in athymic (nude) mice

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2 June 2018

Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo.

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2 June 2018

Stratified phase II trial of cetuximab in patients with recurrent high-grade glioma.

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27 November 2018

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27 November 2018

Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas.

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27 November 2018

Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model

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27 November 2018

Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms.

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27 November 2018

Radioiodinated (I-125) monoclonal antibody 425 in the treatment of high grade glioma patients: ten-year synopsis of a novel treatment.

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27 November 2018

Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion

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27 November 2018

Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas.

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Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas

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based on heuristic

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Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors

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https://pubmed.ncbi.nlm.nih.gov/20305783

12 December 2020

based on heuristic

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Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors

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https://pubmed.ncbi.nlm.nih.gov/20305783

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0009750

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2010PLoSO...5.9750B

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