Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk (Q28473245)

4

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Janet Thornton

object named as

Janet M Thornton

8

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Dominic J Withers

object named as

Dominic J Withers

7

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author name string

Christian Werz

2

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Daniela Wieser

3

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Andrea Foley

5

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Hugo Stocker

6

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Ernst Hafen

Creative Commons Attribution 4.0 International

9

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language of work or name

English

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publication date

19 March 2010

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published in

PLOS Genetics

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volume

6

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page(s)

e1000881

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issue

3

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copyright license

start time

19 March 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

limma

1 reference

Europe PubMed Central

22 June 2022

https://europepmc.org/article/PMC/2841611

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis

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SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase

19 March 2017

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Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation

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Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase

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Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme

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A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

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The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway

7 April 2017

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Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs

29 September 2017

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Optimization of dietary restriction protocols in Drosophila

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Correcting for sequence biases in present/absent calls

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Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

29 September 2017

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SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin

29 September 2017

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Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance

29 September 2017

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Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

29 September 2017

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Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling

29 September 2017

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Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice

29 September 2017

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Lnk adaptor: novel negative regulator of B cell lymphopoiesis

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SH2-B family members differentially regulate JAK family tyrosine kinases

29 September 2017

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Functional effects of APS and SH2-B on insulin receptor signalling

29 September 2017

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Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins

29 September 2017

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29 September 2017

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Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain.

29 September 2017

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29 September 2017

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PSM, an insulin-dependent, pro-rich, PH, SH2 domain containing partner of the insulin receptor

29 September 2017

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Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

29 September 2017

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Adaptor protein SH2-B linking receptor-tyrosine kinase and Akt promotes adipocyte differentiation by regulating peroxisome proliferator-activated receptor gamma messenger ribonucleic acid levels.

29 September 2017

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A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac

2 June 2018

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Adapter protein with a pleckstrin homology (PH) and an Src homology 2 (SH2) domain (APS) and SH2-B enhance insulin-receptor autophosphorylation, extracellular-signal-regulated kinase and phosphoinositide 3-kinase-dependent signalling

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841611

The APS adapter protein couples the insulin receptor to the phosphorylation of c-Cbl and facilitates ligand-stimulated ubiquitination of the insulin receptor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841611

APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841611

Platelet-derived growth factor (PDGF) stimulates the association of SH2-Bbeta with PDGF receptor and phosphorylation of SH2-Bbeta

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2841611

Differential role of SH2-B and APS in regulating energy and glucose homeostasis.

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000881

Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000881

Dietary restriction in long-lived dwarf flies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000881

Long-lived Drosophila with overexpressed dFOXO in adult fat body.

21 January 2018

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Dynamics of the action of dFOXO on adult mortality in Drosophila.

21 January 2018

1 reference

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Input from Ras is required for maximal PI(3)K signalling in Drosophila.

21 January 2018

1 reference

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A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling.

21 January 2018

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Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

21 January 2018

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SH2-B is required for nerve growth factor-induced neuronal differentiation

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20333234