Diverse effects on mitochondrial and nuclear functions elicited by drugs and genetic knockdowns in bloodstream stage Trypanosoma brucei (Q28473842)

April 2022 Public Data File from Crossref

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The KREPA3 zinc finger motifs and OB-fold domain are essential for RNA editing and survival of Trypanosoma brucei

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Turnover of glycosomes during life-cycle differentiation of Trypanosoma brucei

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29 September 2017

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The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei

29 September 2017

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Melarsoprol- and pentamidine-resistant Trypanosoma brucei rhodesiense populations and their cross-resistance

29 September 2017

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Conservation of PEX19-binding motifs required for protein targeting to mammalian peroxisomal and trypanosome glycosomal membranes

29 September 2017

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Autophagy and related processes in trypanosomatids: insights from genomic and bioinformatic analyses

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Species specificity in ribosome biogenesis: a nonconserved phosphoprotein is required for formation of the large ribosomal subunit in Trypanosoma brucei

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A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei

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Quercetin induces apoptosis of Trypanosoma brucei gambiense and decreases the proinflammatory response of human macrophages

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Clathrin-mediated endocytosis is essential in Trypanosoma brucei.

29 September 2017

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Glucose is toxic to glycosome-deficient trypanosomes.

29 September 2017

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RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA.

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Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania

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Posttranscriptional regulation of cytochrome c expression during the developmental cycle of Trypanosoma brucei

29 September 2017

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The TOP2 gene of Trypanosoma brucei: a single-copy gene that shares extensive homology with other TOP2 genes encoding eukaryotic DNA topoisomerase II.

29 September 2017

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29 September 2017

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C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins

29 September 2017

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Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei

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Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.

21 January 2018

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Conservation of the pro-apoptotic nuclease activity of endonuclease G in unicellular trypanosomatid parasites

21 January 2018

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TcPARP: A DNA damage-dependent poly(ADP-ribose) polymerase from Trypanosoma cruzi.

21 January 2018

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Bloodstream form Trypanosoma brucei depend upon multiple metacaspases associated with RAB11-positive endosomes

21 January 2018

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Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form.

21 January 2018

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Prostaglandin-induced programmed cell death in Trypanosoma brucei involves oxidative stress

21 January 2018

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Protein farnesyltransferase inhibitors exhibit potent antimalarial activity

21 January 2018

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An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma brucei

21 January 2018

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RNA interference of Trypanosoma brucei topoisomerase IB: both subunits are essential

21 January 2018

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Distinct genes encode type II Topoisomerases for the nucleus and mitochondrion in the protozoan parasite Trypanosoma brucei

21 January 2018

1 reference

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Propidium iodide-based methods for monitoring drug action in the kinetoplastidae: comparison with the Alamar Blue assay

21 January 2018

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Long-term exposure of Trypanosoma brucei gambiense to pentamidine in vitro

21 January 2018

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Identification of trypanosomatid PEX19: functional characterization reveals impact on cell growth and glycosome size and number.

21 January 2018

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A mitochondrial topoisomerase IA essential for late theta structure resolution in African trypanosomes

21 January 2018

1 reference

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Evolutionary relationships and protein domain architecture in an expanded calpain superfamily in kinetoplastid parasites

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20454560

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20454560

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PNTD.0000678

1 reference

1 reference

1 reference

PubMed publication ID

20454560

1 reference