Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei (Q28483069)

D-ribofuranose 5-phosphate

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1 reference

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1-linoleoyl-sn-glycero-3-phosphocholine

1 reference

1 reference

1 reference

N-(11Z,14Z)-eicosadienoylethanolamine

1 reference

1-palmitoyl-2-arachidonoyl-sn-glycerol

1 reference

N,N-dimethylsphingosine

1 reference

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6-guanidinohexanoic acid

1 reference

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4-acetamidobutyric acid

1 reference

(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylic acid

1 reference

N-(15Z)-tetracosenoylsphingosine

1 reference

1 reference

1 reference

1 reference

gamma-L-glutamylputrescine

1 reference

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N(6),N(6)-dimethyl-L-lysine

1 reference

1 reference

1 reference

1-hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine

1 reference

N-[(13Z)-docosenoyl]sphingosine

1 reference

1 reference

(RS)-pyroglutamic acid

1 reference

1 reference

1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine

1 reference

1 reference

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S-adenosyl-L-homocysteine

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4-guanidinobutyric acid

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phosphorylethanolamine

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N,N-dimethylglycine zwitterion

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glutamate-5-semialdehyde

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N-acetylneuraminic acid

1 reference

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adenosine monophosphate

1 reference

1 reference

1 reference

3-hydroxybenzenepropanoic acid

1 reference

1 reference

7alpha-hydroxycholest-4-en-3-one

1 reference

PC(16:0/20:4(5Z,8Z,11Z,14Z))

colfosceril palmitate

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1 reference

1 reference

1 reference

1 reference

1 reference

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2-Methoxy-5Z-hexadecenoic acid

1 reference

1 reference

N(2)-succinyl-L-ornithine

1 reference

1 reference

2-oxobut-3-enoic acid

1 reference

1 reference

PE(18:1(11Z)/22:2(13Z,16Z))

1 reference

4-hydroxy-1-pyrroline-2-carboxylic acid

1 reference

(R)-3-hydroxybutyric acid

1 reference

1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol

1 reference

1 reference

1 reference

1 reference

1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine

1 reference

1,2-dioleoyl-sn-glycero-3-phospho-(1'-sn-glycerol)

1 reference

(5S)-5-(carboxymethyl)-L-proline

1 reference

1 reference

1 reference

6-acetamido-3-aminohexanoic acid

1 reference

1 reference

1 reference

N-(octadecanoyl)-tetradecasphing-4-enine-1-phosphoethanolamine

1 reference

1-meadoyl-sn-glycero-3-phosphocholine

1 reference

1 reference

1-methyl-5-imidazoleacetic acid

1 reference

1 reference

1 reference

1 reference

21-hydroxyhenicosanoic acid

1 reference

1-hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-phosphocholine

1 reference

PC(14:0/18:3(9Z,12Z,15Z))

1 reference

1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol

1 reference

1-tetradecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine

1 reference

(3S)-3-methyl-2-oxo-pentanoic acid

1 reference

1 reference

sn-glycero-3-phosphocholine

1 reference

1 reference

1 reference

S-adenosyl-L-methionine

1 reference

oleoyl-lysophosphatidylcholine

O-acetyl-L-homoserine

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1 reference

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N-acetyl-L-2-aminoadipic acid

1 reference

PE(18:0/20:4(5Z,8Z,11Z,14Z))

1 reference

(R)-2-hydroxyglutaric acid

(R)-glyceryl 1-phosphate

1 reference

1 reference

1 reference

(2S)-2-isopropyl-3-oxosuccinic acid

1 reference

1 reference

1-oleoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine

1 reference

1 reference

1 reference

DL-p-hydroxyphenyl lactic acid

1 reference

1-(sn-glycero-3-phospho)-1D-myo-inositol

1 reference

1 reference

phenyl hydrogen sulfate

1 reference

1 reference

1 reference

N-acetylneuraminic acid 9-phosphate

1 reference

1 reference

5'-inosine monophosphate

1 reference

1-stearoyl-lysophosphatidylcholine

1 reference

1 reference

1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate

1 reference

1 reference

bis-beta-D-fructofuranose 1,2':2,3'-dianhydride

1 reference

N-myristoylsphingosine-1-phosphocholine

1 reference

(S)-2-hydroxystearic acid

1 reference

(S)-1-pyrroline-5-carboxylic acid

1 reference

1 reference

1 reference

1 reference

PC(16:0/18:3(6Z,9Z,12Z))

1 reference

PG(18:2(9Z,12Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))

1 reference

LysoPC(22:4(7Z,10Z,13Z,16Z))

1 reference

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine

1 reference

1 reference

1-S-[(1Z)-N-(sulfooxy)ethanimidoyl]-1-thio-beta-D-glucopyranose

1 reference

1 reference

N(2)-acetyl-L-ornithine

1 reference

1 reference

guanosine monophosphate

1 reference

1 reference

2-Azaniumyl-5-(ethylamino)-5-oxopentanoate

1 reference

1 reference

1 reference

N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine

1 reference

1 reference

4,4'-methylenebis(2-chloroaniline)

1 reference

1 reference

(1S,6S)-6-amino-octahydroindolizin-1-yl acetate

1 reference

5-guanidino-2-oxopentanoic acid

1 reference

1 reference

1 reference

1 reference

1 reference

N-hexadecanoylsphingosine

1 reference

N(omega)-phospho-L-arginine

1 reference

1 reference

N-ribosylnicotinamide

1 reference

1 reference

1 reference

1 reference

2,2,4-trihydroxybutanoic acid

1 reference

(2R)-1-aminopropan-2-ol

1 reference

4-trimethylammoniobutanoate

1 reference

1 reference

2-Amino-4-((carboxycarbonyl)amino)butanoic acid, (2S)-

1 reference

1-aminocyclopropanecarboxylic acid

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9,10-dihydroxystearic acid

1 reference

1 reference

1 reference

1 reference

1 reference

N-docosanoylsphingosine

1 reference

1 reference

1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine

1 reference

1 reference

1 reference

1 reference

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1 reference

1 reference

S,S-(2-Hydroxyethyl)Thiocysteine

1 reference

O-propanoylcarnitine (internal charge)

1 reference

1 reference

1 reference

1 reference

PG(18:0/22:5(4Z,7Z,10Z,13Z,16Z))

1 reference

PS(18:2(9Z,12Z)/18:2(9Z,12Z))

1 reference

1 reference

1 reference

6-amino-2-oxohexanoic acid

1 reference

1 reference

3-phosphoglyceraldehyde

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1 reference

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1 reference

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indole-3-pyruvic acid

1 reference

1 reference

2-(alpha-D-mannosyl)-D-glyceric acid

1 reference

(2E)-2-hydroxycinnamic acid

1 reference

1 reference

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1 reference

3-(4-hydroxyphenyl)pyruvic acid

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sedoheptulose 7-phosphate

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1 reference

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1 reference

1 reference

(4S,5S)-5'-methylthioadenosine

1 reference

1 reference

1 reference

11-aminoundecanoic acid

1 reference

1 reference

1 reference

gamma-glutamyl-gamma-aminobutyraldehyde

1 reference

1 reference

1 reference

N-octadecanoyl-4-hydroxysphinganine

1 reference

3,4-dihydroxyphenylacetaldehyde

1 reference

1 reference

1 reference

1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine

1 reference

1 reference

1-docosapentaenoyl-sn-glycero-3-phosphocholine

1 reference

N(pros)-methyl-L-histidine

1 reference

1 reference

PG(16:0/20:4(5Z,8Z,11Z,14Z))

1 reference

1,2-dilinoleoyl-sn-glycero-3-phosphate

1 reference

(2E,4E,8E,10E)-dodecatetraenedioic acid

1 reference

1 reference

1 reference

1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine

1 reference

1,2-di-O-pentadecanoyl-sn-glycero-3-phosphocholine

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1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine

1 reference

2-methyl-L-tryptophan

1 reference

2-phosphinomethylmalic acid

1 reference

D-glucuronolactone (open form)

1 reference

1 reference

C18:1DH Sphingomyelin

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

N-acetyl-D-glucosamine 6-phosphate

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1 reference

1 reference

1 reference

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1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

(2S)-2-hydroxy-2-methyl-3-oxobutanoic acid

1 reference

1 reference

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glycodeoxycholic acid

1 reference

1 reference

N(6)-[(indol-3-yl)acetyl]-L-lysine

1 reference

1 reference

1 reference

D-glucitol 6-phosphate

1 reference

N-docosanoylsphingosine-1-phosphocholine

1 reference

1-tetradecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-phosphocholine

1 reference

1 reference

1 reference

1-[(9Z)-hexadecenoyl]-sn-glycero-3-phosphocholine

1 reference

3alpha,12alpha-Dihydroxy-5beta-chol-6-en-24-oic acid

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

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1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine

1 reference

1 reference

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cyclo(DeltaAla-L-Val)

1 reference

1 reference

1 reference

1 reference

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N(6)-(dimethylallyl)adenosine 5'-triphosphate

1 reference

1 reference

1 reference

lysophosphatidic acid 0:0/18:2(9Z,12Z)

1 reference

1 reference

1 reference

1 reference

1 reference

1-linoleoyl-sn-glycero-3-phosphoethanolamine

1 reference

1 reference

PE(18:1(9Z)/18:2(9Z,12Z))

1 reference

1 reference

PC(14:1(9Z)/16:1(9Z))

1 reference

1 reference

PS(16:0/18:2(9Z,12Z))

1 reference

CDP-choline (neutral charge)

N-Acetyl-D-Glucosamine

1 reference

1 reference

1 reference

1-(11Z-octadecenyl)-sn-glycero-3-phosphocholine

1 reference

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3-phospho-D-glyceric acid

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phosphoenolpyruvic acid

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phosphocholine cation

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1 reference

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alpha,alpha-trehalose 6-phosphate

1 reference

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5-hydroxyvaleric acid

1 reference

1 reference

L-methionine (RS)-S-oxide

1 reference

dehydrodeoxycoformycin

1 reference

4-(methylthio)-2-oxobutanoic acid

1 reference

N-icosanoylsphingosine-1-phosphocholine

1 reference

PC(18:1(9Z)/20:3(5Z,8Z,11Z))

1 reference

1 reference

L-cysteine sulphinic acid

1 reference

2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol

1 reference

(13Z)-8-hydroxyoctadecene-9,11-diynoic acid

1 reference

1 reference

1 reference

2-acetamido-5-oxopentanoic acid

1 reference

1 reference

glycine betaine aldehyde

1 reference

1 reference

N-hexadecanoylphytosphingosine

1 reference

N-methylethanolamine phosphate

1 reference

1 reference

1,2-dilinoleoyl-sn-glycero-3-phospho-1D-myo-inositol

1 reference

1-[(9Z)-hexadecenoyl]-2-[(11Z)-octadecenoyl]-sn-glycero-3-phosphocholine

1 reference

1 reference

1 reference

PC(P-16:0/18:2(9Z,12Z))

1 reference

PG(18:0/22:4(7Z,10Z,13Z,16Z))

N-palmitoylsphingomyelin

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

16-hydroxypalmitic acid

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

2-linoleoyl-sn-glycero-3-phosphoethanolamine

1 reference

1 reference

1 reference

N-octadecanoylsphingosine

1 reference

1 reference

(24R)-1alpha,24-dihydroxy-22-oxavitamin D3

1 reference

1 reference

Sphinganine-1-phosphocholine

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

3-methyl-2-oxobutyric acid

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

6-acetamido-2-oxohexanoic acid

1 reference

cytidine monophosphate

1 reference

(S)-2-azetidinecarboxylic acid

N(1)-acetylspermidine

1 reference

1 reference

1 reference

1 reference

S-methyl-L-methionine

1 reference

DG(16:1(9Z)/20:1(11Z)/0:0)

1 reference

1-arachidonoyl-sn-glycero-3-phosphocholine

1 reference

1 reference

1-Stearoyl-2-docosahexaenoyl-sn-glycerol

1 reference

1 reference

N-methylimidazoleacetic acid

1 reference

(+/-)-acetylcarnitine

1 reference

1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine

1 reference

1-stearoyl-2-linoleoyl-sn-glycero-3-phosphate

1 reference

1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine

1 reference

PC(18:2(9Z,12Z)/18:1(9Z))

1 reference

1 reference

1 reference

1 reference

1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine

1 reference

1 reference

N-undecylundecan-1-amine

1 reference

1,2-dioleoyl-sn-glycero-3-phosphocholine

1 reference

1 reference

PA(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))

1 reference

PG(16:0/20:3(5Z,8Z,11Z))

1 reference

N-oleoylsphingosine-1-phosphocholine

1 reference

N-hexadecanoylsphingosine 1-phosphate

1 reference

1 reference

N-(13Z-docosenoyl)-sphing-4-enine-1-phosphocholine

1 reference

PA(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))

1 reference

1 reference

1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-D-myo-inositol

1 reference

4,7-dioxooctanoic acid

1 reference

PC(16:0/18:3(9Z,12Z,15Z))

1 reference

1,2-dilinoleoyl-sn-glycero-3-phosphocholine

1 reference

N-(4-aminohepta-5,6-dien-1-yl)guanidine

1 reference

6

Michael P Barrett

0 references

Isabel Vincent

object named as

Isabel M Vincent

1

0 references

Karl V Burgess

object named as

Karl Burgess

3

0 references

Darren J Creek

object named as

Darren J Creek

2

0 references

author name string

Debra J Woods

4

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Richard J S Burchmore

5

0 references

Michael P Barrett

full work available at URL

6

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language of work or name

English

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publication date

2012

0 references

https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0001618&type=printable

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1371/journal.pntd.0001618?email=unpaywall_01@example.com

published in

PLoS Neglected Tropical Diseases

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volume

6

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issue

5

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page(s)

e1618

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copyright license

Creative Commons Attribution 2.5 Generic

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on focus list of Wikimedia project

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1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1371/journal.pntd.0001618?email=unpaywall_01@example.com

access restriction status

open access

1 reference

inferred from online access status

cites work

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29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

ACETYLORNITHINE DELTA-TRANSAMINASE. PARTIAL PURIFICATION AND REPRESSION BEHAVIOR

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Genomic organisation and transcription characterisation of the gene encoding Leishmania (Leishmania) amazonensis arginase and its protein structure prediction.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Arsenical-resistant trypanosomes lack an unusual adenosine transporter

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Recent research on the biological activity of suramin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Cultivation of bloodstream Trypanosoma brucei

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Automated mode-of-action detection by metabolic profiling.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Fluorescence polarization studies on Escherichia coli membrane stability and its relation to the resistance of the cell to freeze-thawing. II. Stabilization of the membranes by polyamines.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Human African trypanosomiasis

2 June 2018

2 references

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001618

21 January 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Mode of action of nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: is oxidative stress involved?

27 November 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001618

In vivo effects of alpha-DL-difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001618

Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001618

An effect of parasite-encoded arginase on the outcome of murine cutaneous leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001618

Biochemical and biophysical properties of a highly active recombinant arginase from Leishmania (Leishmania) amazonensis and subcellular localization of native enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001618

Trypanosoma brucei brucei: characterization of an ODC null bloodstream form mutant and the action of alpha-difluoromethylornithine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001618

Transketolase in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001618

Transport of methionine in Trypanosoma brucei brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001618

GC-MS-based metabolomics reveals mechanism of action for hydrazine induced hepatotoxicity in rats

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

27 November 2018

Pentamidine: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Necessity of antibody response in the treatment of African trypanosomiasis with alpha-difluoromethylornithine

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei

27 November 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001618

The enzymes of the classical pentose phosphate pathway display differential activities in procyclic and bloodstream forms of Trypanosoma brucei

21 January 2018

1 reference

12 December 2020

Polyamines as a defense mechanism against lipoperoxidation in Trypanosoma cruzi

1 reference

12 December 2020

Hydrogen peroxide metabolism in Trypanosoma brucei

1 reference

12 December 2020

Trypanosoma cruzi: Oxidative stress induces arginine kinase expression

1 reference

12 December 2020

2009 FDA drug approvals

1 reference

12 December 2020

10.1371/JOURNAL.PNTD.0001618

Identifiers

DOI

1 reference

3644474

3644474

1 reference

1 reference

1 reference