Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis (Q28486804)

24 January 2017

title

Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis (English)

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Mycobacterium tuberculosis

24 January 2017

main subject

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Luke J. Alderwick

1

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24 January 2017

Mathias Seidel

2

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24 January 2017

Hermann Sahm

3

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24 January 2017

Gurdyal S. Besra

4

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24 January 2017

Lothar Eggeling

5

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24 January 2017

language of work or name

English

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publication date

9 June 2006

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Journal of Biological Chemistry

24 January 2017

published in

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24 January 2017

volume

281

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24 January 2017

issue

23

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24 January 2017

page(s)

15653–15661

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Tuberculosis: commentary on a reemergent killer

24 January 2017

cites work

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Deletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan-deficient mutant with a cell wall galactan core

21 January 2018

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The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol

21 January 2018

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The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol.

21 January 2018

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Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis

21 January 2018

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The role of the embA and embB gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan.

21 January 2018

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The Emb proteins of mycobacteria direct arabinosylation of lipoarabinomannan and arabinogalactan via an N‐terminal recognition region and a C‐terminal synthetic region

21 January 2018

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Roles of conserved proline and glycosyltransferase motifs of EmbC in biosynthesis of lipoarabinomannan

21 January 2018

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Cell wall core galactofuran synthesis is essential for growth of mycobacteria

21 January 2018

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Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability

21 January 2018

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Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis

21 January 2018

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Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis

21 January 2018

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A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms

21 January 2018

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Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum

21 January 2018

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Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl ribose

21 January 2018

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Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-{alpha}-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesis

21 January 2018

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Synthesis of beta-D-arabinofuranosyl-1-monophosphoryl polyprenols: examination of their function as mycobacterial arabinosyl transferase donors.

21 January 2018

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Structure of the cell envelope of corynebacteria: importance of the non-covalently bound lipids in the formation of the cell wall permeability barrier and fracture plane

21 January 2018

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21 January 2018

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Prediction of transmembrane alpha-helices in prokaryotic membrane proteins: the dense alignment surface method

21 January 2018

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Three monophyletic superfamilies account for the majority of the known glycosyltransferases

21 January 2018

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Genes required for mycobacterial growth defined by high density mutagenesis

21 January 2018

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The Envelope of Mycobacteria

21 January 2018

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Ethambutol, a cell wall inhibitor of Mycobacterium tuberculosis, elicits L-glutamate efflux of Corynebacterium glutamicum

21 January 2018

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21 January 2018

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Comparative cell wall core biosynthesis in the mycolated pathogens, Mycobacterium tuberculosis and Corynebacterium diphtheriae

21 January 2018

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Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferase

21 January 2018

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Biosynthesis of the galactan component of the mycobacterial cell wall

21 January 2018

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Mycobacterial arabinan biosynthesis: the use of synthetic arabinoside acceptors in the development of an arabinosyl transfer assay

21 January 2018

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Synthesis of the Arabinose Donor .beta.-D-Arabinofuranosyl-1-monophosphoryldecaprenol, Development of a Basic Arabinosyl-Transferase Assay, and Identification of Ethambutol as an Arabinosyl Transferase Inhibitor

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M600045200

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