Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose (Q28486980)

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Language	Label	Description	Also known as
English	Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose	scientific journal article

Statements

scholarly article

1 reference

24 January 2017

Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose (English)

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24 January 2017

Mycobacterium tuberculosis

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dTDP-4-dehydro-beta-L-rhamnose(2-)

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ChEBI release 2020-05-28

dTDP-4-dehydro-6-deoxy-alpha-D-glucose(2-)

1 reference

ChEBI release 2020-05-28

dTDP-4-dehydro-beta-L-rhamnose

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ChEBI release 2020-05-28

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based on heuristic

inferred from title

author name string

Y. Ma

1

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24 January 2017

R. J. Stern

2

1 reference

24 January 2017

M. S. Scherman

3

1 reference

24 January 2017

V. D. Vissa

4

1 reference

24 January 2017

W. Yan

5

1 reference

24 January 2017

V. C. Jones

6

1 reference

24 January 2017

F. Zhang

7

1 reference

24 January 2017

S. G. Franzblau

8

1 reference

24 January 2017

W. H. Lewis

9

1 reference

24 January 2017

M. R. McNeil

10

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24 January 2017

language of work or name

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publication date

1 May 2001

1 reference

24 January 2017

Antimicrobial Agents and Chemotherapy

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24 January 2017

45

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24 January 2017

5

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24 January 2017

1407–1416

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24 January 2017

The enzymic synthesis of thymidine-linked sugars. I. Thymidine diphosphate glucose

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19 March 2017

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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19 March 2017

RmlC, the third enzyme of dTDP-L-rhamnose pathway, is a new class of epimerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90481

19 March 2017

A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases

1 reference

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19 March 2017

Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update

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19 March 2017

Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis

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Construction and use of low-copy number T7 expression vectors for purification of problem proteins: purification of mycobacterium tuberculosis RmlD and pseudomonas aeruginosa LasI and RhlI proteins, and functional analysis of purified RhlI

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19 March 2017

Conversion of dTDP-4-keto-6-deoxyglucose to free dTDP-4-keto-rhamnose by the rmIC gene products of Escherichia coli and Mycobacterium tuberculosis

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19 March 2017

GDP-L-fucose pyrophosphorylase. Purification, cDNA cloning, and properties of the enzyme

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Biosynthetic origin of mycobacterial cell wall galactofuranosyl residues

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Mycobacterial lipoarabinomannan: an extraordinary lipoheteroglycan with profound physiological effects

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Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium

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19 March 2017

Determination of the pathway for rhamnose biosynthesis in mycobacteria: cloning, sequencing and expression of the Mycobacterium tuberculosis gene encoding alpha-D-glucose-1-phosphate thymidylyltransferase

1 reference

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19 March 2017

Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid

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19 March 2017

The Envelope of Mycobacteria

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19 March 2017

The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90481

19 March 2017

Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90481

19 March 2017

Overexpression, purification, crystallization and preliminary structural study of dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD), the fourth enzyme of the dTDP-L-rhamnose synthesis pathway, from Salmonella enterica serovar Typhimurium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90481

29 September 2017

Nucleotide sequence of the rhamnose biosynthetic operon of Shigella flexneri 2a and role of lipopolysaccharide in virulence

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29 September 2017

Recognition of multiple effects of ethambutol on metabolism of mycobacterial cell envelope

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29 September 2017

Structure of the O antigen of Escherichia coli K-12 and the sequence of its rfb gene cluster

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90481

29 September 2017

Altered deoxyribonucleotide pools in P2 eductants of Escherichia coli K-12 due to deletion of the dcd gene

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29 September 2017

New horizons in the treatment of tuberculosis

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2 June 2018

Substrate specificity of native dTDP-D-glucose-4,6-dehydratase: chemo-enzymatic syntheses of artificial and naturally occurring deoxy sugars.

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Intramolecular hydrogen transfer catalyzed by UDP-D-glucose 4'-epimerase from Escherichia coli.

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2 June 2018

Sequence and structural analysis of the rfb (O antigen) gene cluster from a group C1 Salmonella enterica strain

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The purification, crystallization and structural elucidation of dTDP-D-glucose 4,6-dehydratase (RmlB), the second enzyme of the dTDP-L-rhamnose synthesis pathway from Salmonella enterica serovar typhimurium.

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Characterization of dTDP-4-dehydrorhamnose 3,5-epimerase and dTDP-4-dehydrorhamnose reductase, required for dTDP-L-rhamnose biosynthesis in Salmonella enterica serovar Typhimurium LT2.

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1 reference

https://pubmed.ncbi.nlm.nih.gov/11302803

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.1128/JB.126.2.999-1001.1976

Identifiers

10.1128/AAC.45.5.1407-1416.2001

1 reference

24 January 2017

0 references

1 reference

24 January 2017

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