pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis (Q28504532)

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English	pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis	scientific journal article

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scholarly article

1 reference

24 January 2017

pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis (English)

1 reference

24 January 2017

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Pancreatic and duodenal homeobox 1

1 reference

GOA release 2020-03-11

Elizabeth T. Ables

object named as

Elizabeth Tweedie Ables

2

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object named as

Mark A. Magnuson

6

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author name string

Maureen Gannon

1

1 reference

24 January 2017

Laura Crawford

3

1 reference

24 January 2017

David Lowe

4

1 reference

24 January 2017

Martin F. Offield

5

1 reference

24 January 2017

Christopher V. E. Wright

7

1 reference

24 January 2017

language of work or name

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publication date

15 February 2008

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24 January 2017

Developmental Biology

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24 January 2017

314

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24 January 2017

2

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24 January 2017

406–417

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24 January 2017

The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

19 March 2017

Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

19 March 2017

Notch signaling controls multiple steps of pancreatic differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

19 March 2017

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

19 March 2017

Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

19 March 2017

Notch signalling controls pancreatic cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

19 March 2017

Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

19 March 2017

Generalized lacZ expression with the ROSA26 Cre reporter strain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

19 March 2017

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

19 March 2017

The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

19 March 2017

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

19 March 2017

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

19 March 2017

Tissue- and site-specific DNA recombination in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

19 March 2017

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

7 April 2017

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

7 April 2017

Insulin-promoter-factor 1 is required for pancreas development in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

7 April 2017

RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

29 September 2017

Gene regulatory factors in pancreatic development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

29 September 2017

Gene expression cascades in pancreatic development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

29 September 2017

Experimental control of pancreatic development and maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

29 September 2017

Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

29 September 2017

Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

29 September 2017

Developmental expression of proprotein convertase 1/3 in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

29 September 2017

Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

29 September 2017

beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

29 September 2017

Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

29 September 2017

Phenotypic alterations in insulin-deficient mutant mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

29 September 2017

Beta cells arise from glucose transporter type 2 (Glut2)-expressing epithelial cells of the developing rat pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

29 September 2017

Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

29 September 2017

Histone Phosphorylation and Chromatin Structure during Mitosis in Chinese Hamster Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

29 September 2017

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

2 June 2018

Autonomous endodermal determination in Xenopus: regulation of expression of the pancreatic gene XlHbox 8.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

2 June 2018

Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

2 June 2018

The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

27 November 2018

Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

27 November 2018

Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

27 November 2018

Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

27 November 2018

Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

27 November 2018

Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

27 November 2018

Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

27 November 2018

Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

27 November 2018

Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

27 November 2018

Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

27 November 2018

Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

27 November 2018

Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

27 November 2018

Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2269701

27 November 2018

Gender differences in the metabolic response to graded numbers of transplanted islets of Langerhans

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2007.10.038

7 January 2021

Regulatory factor linked to late-onset diabetes?

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2007.10.038

7 January 2021

Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2007.10.038

7 January 2021

Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2007.10.038

7 January 2021

Attenuation of FGF signalling in mouse β-cells leads to diabetes

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2007.10.038

7 January 2021

Growth dynamics of pancreatic islet cell populations during fetal and neonatal development of the rat

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2007.10.038

7 January 2021

The mojo of methylation

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2007.10.038

7 January 2021

Studies on sex dependency of B-cell susceptibility to streptozotocin in a rat model of type II diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2007.10.038

7 January 2021

An ultrastructural analysis of the developing embryonic pancreas

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2007.10.038

7 January 2021

Glucagon is required for early insulin-positive differentiation in the developing mouse pancreas

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2007.10.038

7 January 2021

The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2007.10.038

7 January 2021

The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2007.10.038

7 January 2021

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2007.10.038

7 January 2021

Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2007.10.038

7 January 2021

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18155690

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18155690

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/18155690

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

1 reference

https://pubmed.ncbi.nlm.nih.gov/18155690

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.YDBIO.2007.10.038

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

release_noa2oqgxsrddxo2bptvlv2dpru

1 reference

https://api.fatcat.wiki/v0/release/noa2oqgxsrddxo2bptvlv2dpru

24 November 2022

based on heuristic

mapped directly with Wikidata item

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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