Insulin inhibits lipolysis in adipocytes via the evolutionarily conserved mTORC1-Egr1-ATGL-mediated pathway (Q28505405)

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5 March 2020

title

Insulin inhibits lipolysis in adipocytes via the evolutionarily conserved mTORC1-Egr1-ATGL-mediated pathway (English)

2 references

24 January 2017

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5 March 2020

1 reference

GOA release 2020-03-11

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1 reference

8

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5 March 2020

Kathrin H Kirsch

9

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5 March 2020

Susan K Fried

10

1 reference

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5 March 2020

Konstantin Kandror

11

1 reference

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5 March 2020

author name string

Partha Chakrabarti

1

2 references

24 January 2017

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5 March 2020

Ju Youn Kim

2

2 references

24 January 2017

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5 March 2020

Maneet Singh

3

2 references

24 January 2017

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5 March 2020

Yu-Kyong Shin

4

2 references

24 January 2017

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5 March 2020

Jessica Kim

5

2 references

24 January 2017

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5 March 2020

Joerg Kumbrink

6

2 references

24 January 2017

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5 March 2020

Yuanyuan Wu

7

2 references

24 January 2017

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5 March 2020

language of work or name

English

0 references

publication date

15 July 2013

1 reference

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Molecular and Cellular Biology

5 March 2020

published in

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volume

33

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5 March 2020

page(s)

3659-3666

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5 March 2020

issue

18

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24 January 2017

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Fatty acids, obesity, and insulin resistance: time for a reevaluation

5 March 2020

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PPARgamma agonism increases rat adipose tissue lipolysis, expression of glyceride lipases, and the response of lipolysis to hormonal control

19 March 2017

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19 March 2017

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Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt

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Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL

29 September 2017

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Early growth response 1 (Egr1) regulates cholesterol biosynthetic gene expression

29 September 2017

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Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling

29 September 2017

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Transcriptional control of adipose lipid handling by IRF4

29 September 2017

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An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism

29 September 2017

1 reference

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High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila

29 September 2017

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EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.

29 September 2017

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Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage

29 September 2017

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Lipolysis and lipid mobilization in human adipose tissue

29 September 2017

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Mediator MED23 links insulin signaling to the adipogenesis transcription cascade

29 September 2017

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The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation.

29 September 2017

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Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis

29 September 2017

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Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores

29 September 2017

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29 September 2017

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PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.

29 September 2017

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29 September 2017

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Regulation of lipolysis in adipocytes

29 September 2017

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29 September 2017

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Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

29 September 2017

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Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin

29 September 2017

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29 September 2017

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Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase

29 September 2017

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Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis.

29 September 2017

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Expression Profiling Identifies Genes That Continue to Respond to Insulin in Adipocytes Made Insulin-resistant by Treatment with Tumor Necrosis Factor-α

29 September 2017

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Regulation of life and death by the zinc finger transcription factor Egr-1.

29 September 2017

1 reference

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Identification of two polymorphisms in the early growth response protein-1 gene: possible association with lipid variables

29 September 2017

1 reference

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Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G(0)/G(1) switch gene 2 (G0S2) protein and mRNA content in human adipose tissue

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753874

Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway

2 June 2018

1 reference

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Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes

2 June 2018

1 reference

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FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes

2 June 2018

1 reference

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Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3753874

The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPARgamma

2 June 2018

1 reference

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Translocation of small preformed vesicles is responsible for the insulin activation of glucose transport in adipose cells. Evidence from the in vitro reconstitution assay.

2 June 2018

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Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state.

2 June 2018

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Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity.

27 November 2018

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Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila

27 November 2018

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Isoproterenol, TNFalpha, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes

27 November 2018

1 reference

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Hormone-sensitive lipase-independent adipocyte lipolysis during beta-adrenergic stimulation, fasting, and dietary fat loading.

27 November 2018

1 reference

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Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

27 November 2018

1 reference

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What if Minkowski had been ageusic? An alternative angle on diabetes

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23858058

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Type 2 diabetes: pathogenesis and treatment

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23858058

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23858058

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.01584-12

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858058%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23858058%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

2 references