Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport (Q28506553)

NPC intracellular cholesterol transporter 1

GOA release 2020-03-11

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Niemann–Pick disease, type C

GOA release 2020-03-11

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6

Frances M. Platt

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24 January 2017

Danielle te Vruchte

1

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24 January 2017

Emyr Lloyd-Evans

2

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24 January 2017

Robert Jan Veldman

3

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24 January 2017

David C. A. Neville

4

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24 January 2017

Raymond A. Dwek

5

1 reference

24 January 2017

Wim J. van Blitterswijk

7

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24 January 2017

Dan J. Sillence

Journal of Biological Chemistry

8

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24 January 2017

language of work or name

English

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publication date

18 June 2004

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24 January 2017

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24 January 2017

279

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24 January 2017

25

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24 January 2017

26167–26175

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24 January 2017

Localization of globoside and Forssman glycolipids on erythrocyte membranes

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https://api.crossref.org/works/10.1074%2FJBC.M311591200

Lipid sorting in epithelial cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311591200

Lipid rafts: elusive or illusive?

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311591200

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311591200

Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311591200

Glycosphingolipids internalized via caveolar-related endocytosis rapidly merge with the clathrin pathway in early endosomes and form microdomains for recycling.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311591200

The endocytic pathway: a mosaic of domains

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311591200

Broad screening test for sphingolipid-storage diseases.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311591200

Jamming the endosomal system: lipid rafts and lysosomal storage diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Glycosphingolipids are not essential for formation of detergent-resistant membrane rafts in melanoma cells. methyl-beta-cyclodextrin does not affect cell surface transport of a GPI-anchored protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Lipid rafts make for slippery platforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Annexin II regulates multivesicular endosome biogenesis in the degradation pathway of animal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells

21 January 2018

1 reference

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Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

The annexin II2p11(2) complex is the major protein component of the triton X-100-insoluble low-density fraction prepared from MDCK cells in the presence of Ca2+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Cell confluence-dependent remodeling of endothelial membranes mediated by cholesterol.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311591200

Specific release of membrane-bound annexin II and cortical cytoskeletal elements by sequestration of membrane cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Calcium-dependent association of annexin VI, protein kinase C alpha, and neurocalcin alpha on the raft fraction derived from the synaptic plasma membrane of rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Cholesterol modulates the membrane binding and intracellular distribution of annexin 6.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311591200

Evidence for the Involvement of annexin 6 in the trafficking between the endocytic compartment and lysosomes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311591200

Late endosome motility depends on lipids via the small GTPase Rab7.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311591200

Critical role for glycosphingolipids in Niemann-Pick disease type C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Caveolae purification and glycosylphosphatidylinositol-linked protein sorting in polarized epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311591200

Isolation of complex gangliosides from human brain

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311591200

Ionization and fragmentation of neutral and acidic glycosphingolipids with a Q-TOF mass spectrometer fitted with a MALDI ion source

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Lipid changes in Niemann-Pick disease type C brain: personal experience and review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

A neutral sphingomyelinase resides in sphingolipid-enriched microdomains and is inhibited by the caveolin-scaffolding domain: potential implications in tumour necrosis factor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Localization of neutral ceramidase in caveolin-enriched light membranes of murine endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Type C Niemann-Pick disease: a murine model of the lysosomal cholesterol lipidosis accumulates sphingosine and sphinganine in liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Free sphingoid bases in tissues from patients with type C Niemann-Pick disease and other lysosomal storage disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Type C Niemann-Pick disease: use of hydrophobic amines to study defective cholesterol transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Cholesterol modulates membrane traffic along the endocytic pathway in sphingolipid-storage diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Glucosylceramide modulates membrane traffic along the endocytic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Annexins in cell membrane dynamics. Ca(2+)-regulated association of lipid microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Cessation of rapid late endosomal tubulovesicular trafficking in Niemann-Pick type C1 disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Apoptosis and signalling in acid sphingomyelinase deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann-Pick C1-deficient cells

21 January 2018

1 reference

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Gangliosides are receptors for murine polyoma virus and SV40

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Storage diseases: new insights into sphingolipid functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

CD77-dependent retrograde transport of CD19 to the nuclear membrane: functional relationship between CD77 and CD19 during germinal center B-cell apoptosis

21 January 2018

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Targeting of Shiga toxin B-subunit to retrograde transport route in association with detergent-resistant membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Ganglioside structure dictates signal transduction by cholera toxin and association with caveolae-like membrane domains in polarized epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Variations among cell lines in the synthesis of sphingolipids in de novo and recycling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Calcium and calmodulin in membrane fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Identification of the gene causing mucolipidosis type IV.

21 January 2018

1 reference

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Identification and characterization of the single channel function of human mucolipin-1 implicated in mucolipidosis type IV, a disorder affecting the lysosomal pathway

21 January 2018

1 reference

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Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms

21 January 2018

1 reference

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Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin

21 January 2018

1 reference

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Enhanced insulin sensitivity in mice lacking ganglioside GM3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Embryonic Striatal Neurons from Niemann-Pick Type C Mice Exhibit Defects in Cholesterol Metabolism and Neurotrophin Responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Mass spectrometric analysis reveals an increase in plasma membrane polyunsaturated phospholipid species upon cellular cholesterol loading

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Sphingolipid Metabolism during Infection of Human Fibroblasts by Herpes Simplex Virus Type 1

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Human genetics. Jewish lysosomes

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Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis

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https://api.crossref.org/works/10.1074%2FJBC.M311591200

Lipid traffic in animal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Transmembrane molecular pump activity of Niemann-Pick C1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

Identification of HE1 as the second gene of Niemann-Pick C disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311591200

MLN64 mediates mobilization of lysosomal cholesterol to steroidogenic mitochondria

21 January 2018

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