The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity (Q28506782)

GOA release 2020-03-11

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H. Kagechika

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Philippe Froguel

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P. Froguel

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T. Yamauchi

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J. Kamon

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T. Ide

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K. Murakami

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N. Tsuboyama-Kasaoka

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O. Ezaki

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Y. Akanuma

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O. Gavrilova

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C. Vinson

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M. L. Reitman

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K. Shudo

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T. Kadowaki

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Y. Nakano

Obesity in the new millennium

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language of work or name

English

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publication date

1 August 2001

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AdipoQ is a novel adipose-specific gene dysregulated in obesity

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Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity

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Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24.

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Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome.

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PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

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Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency

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Retinoid X receptor-antagonistic diazepinylbenzoic acids

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Roles of PPARs in health and disease.

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Adipogenesis and obesity: rounding out the big picture

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Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

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Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

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C1qâ how many functions? How many receptors?

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7 January 2021

The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor

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Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner.

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PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL

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A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats

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Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

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Towards a molecular understanding of adaptive thermogenesis

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Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression.

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Cellular mechanisms of insulin resistance

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Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: usefulness of leptin for the treatment of obesity-associated diabetes.

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Genetics of non-insulin-dependent (type-II) diabetes mellitus

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Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway

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Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice

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7 January 2021