Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation (Q28506917)

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8 January 2020

title

Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation (English)

2 references

24 January 2017

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8 January 2020

1 reference

GOA release 2020-03-11

author

Christopher J. Lengner

series ordinal

1

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5

Andre J van Wijnen

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8

Gary S Stein

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8 January 2020

7

Jane B Lian

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8 January 2020

6

Janet L Stein

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8 January 2020

4

Christoph Lepper

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8 January 2020

author name string

Mohammad Q Hassan

series ordinal

2

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8 January 2020

Ryan W Serra

series ordinal

3

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8 January 2020

language of work or name

English

0 references

publication date

8 February 2005

1 reference

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Journal of Biological Chemistry

8 January 2020

published in

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volume

280

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issue

16

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page(s)

15872-15879

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Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling

8 January 2020

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Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

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Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites.

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Smad-Dependent Recruitment of a Histone Deacetylase/Sin3A Complex Modulates the Bone Morphogenetic Protein-Dependent Transcriptional Repressor Activity of Nkx3.2

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The chick transcriptional repressor Nkx3.2 acts downstream of Shh to promote BMP-dependent axial chondrogenesis.

21 January 2018

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The mouse bagpipe gene controls development of axial skeleton, skull, and spleen

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Targeted disruption of the homeobox transcription factor Bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation.

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Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

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Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

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Activation of the bone-related Runx2/Cbfa1 promoter in mesenchymal condensations and developing chondrocytes of the axial skeleton

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Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons

21 January 2018

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The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons

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Causal relationship between the loss of RUNX3 expression and gastric cancer

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Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor

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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

21 January 2018

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Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors

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Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development

21 January 2018

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Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex

21 January 2018

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High density micromass cultures of embryonic limb bud mesenchymal cells: an in vitro model of endochondral skeletal development

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Identification of novel protein/DNA interactions within the promoter of the bone-related transcription factor Runx2/Cbfa1.

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Characterization of Nkx3.2 DNA binding specificity and its requirement for somitic chondrogenesis

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BMP-2 and sonic hedgehog have contrary effects on adipocyte-like differentiation of C3H10T1/2 cells.

21 January 2018

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Parathyroid hormone-related peptide interacts with bone morphogenetic protein 2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T 1/2 mesenchymal cells

21 January 2018

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Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway

21 January 2018

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Chondrogenic differentiation of murine C3H10T1/2 multipotential mesenchymal cells: I. Stimulation by bone morphogenetic protein-2 in high-density micromass cultures.

21 January 2018

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In vitro and in vivo synergistic interactions between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation

21 January 2018

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Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12.

21 January 2018

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Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein

21 January 2018

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Cbfa1 couples chondrocytes maturation and endochondral ossification in rat mandibular condylar cartilage

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Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice

21 January 2018

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Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling

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Role of Runx genes in chondrocyte differentiation

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Hierarchy revealed in the specification of three skeletal fates by Sox9 and Runx2.

21 January 2018

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21 January 2018

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Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis.

21 January 2018

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BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2.

21 January 2018

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The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation

21 January 2018

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21 January 2018

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1,25-(OH)2-vitamin D3 suppresses the bone-related Runx2/Cbfa1 gene promoter

21 January 2018

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Bone morphogenetic protein-2 enhances osterix gene expression in chondrocytes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M411144200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703179%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

2 references

24 January 2017