Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition (Q28508200)

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English	Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition	scientific journal article

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scholarly article

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PubMed publication ID

24 January 2017

Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition (English)

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PubMed publication ID

24 January 2017

Glutamate receptor, ionotropic, NMDA2A (epsilon 1)

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GOA release 2020-03-11

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author name string

Will Spooren

1

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PubMed publication ID

24 January 2017

Cedric Mombereau

2

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PubMed publication ID

24 January 2017

Martine Maco

3

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PubMed publication ID

24 January 2017

Rammy Gill

4

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24 January 2017

John A. Kemp

5

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PubMed publication ID

24 January 2017

Laurence Ozmen

6

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PubMed publication ID

24 January 2017

Shigetada Nakanishi

7

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24 January 2017

Guy A. Higgins

8

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24 January 2017

language of work or name

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publication date

1 August 2004

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24 January 2017

Psychopharmacology

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24 January 2017

175

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24 January 2017

1

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24 January 2017

99–105

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24 January 2017

N-methyl-D-aspartic acid receptor structure and function

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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The anti-ischaemic drug, eliprodil, blocks hyperactivity induced by intra-accumbens injection of spermine

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Clinical experience with excitatory amino acid antagonist drugs

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Role of dopaminergic mechanisms in the stimulatory effects of MK-801 injected into the ventral tegmental area and the nucleus accumbens

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat.

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Differences between three rat strains in sensitivity to prepulse inhibition of an acoustic startle response: influence of apomorphine and phencyclidine pretreatment.

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Multiple limbic regions mediate the disruption of prepulse inhibition produced in rats by the noncompetitive NMDA antagonist dizocilpine.

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Inbred strain differences in prepulse inhibition of the mouse startle response

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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NMDA receptor pathways as drug targets

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Gating and habituation of the startle reflex in schizophrenic patients

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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The messenger RNAs for the N-methyl-D-aspartate receptor subunits show region-specific expression of different subunit composition in the human brain

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Expression of N-methyl- d-aspartate glutamate receptor subunits in the prefrontal cortex of the rat

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Assessment of locomotor activity, acoustic and tactile startle, and prepulse inhibition of startle in inbred mouse strains and F1 hybrids: implications of genetic background for single gene and quantitative trait loci analyses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

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Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Disruption of prepulse inhibition and increases in locomotor activity by competitive N-methyl-D-aspartate receptor antagonists in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Antagonists selective for NMDA receptors containing the NR2B subunit.

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

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The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

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Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

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Comparison of various N-methyl-D-aspartate receptor antagonists in a model of short-term memory and on overt behaviour.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

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Prepulse inhibition of the startle reflex in rats: effects of compounds acting at various sites on the NMDA receptor complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Nitric oxide synthase inhibitors attenuate phencyclidine-induced disruption of prepulse inhibition

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Recent advances in the phencyclidine model of schizophrenia

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Transgenic and knock-out mouse pups: the growing need for behavioral analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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The behavioral pharmacology of NMDA receptor antagonists

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Competitive NMDA receptor antagonists do not produce locomotor hyperactivity by a dopamine-dependent mechanism

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

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Substitution for PCP, disruption of prepulse inhibition and hyperactivity induced by N-methyl-D-aspartate receptor antagonists: preferential involvement of the NR2B rather than NR2A subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-004-1785-Y

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PubMed publication ID

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PubMed publication ID

24 January 2017

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