Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver (Q28509001)

24 January 2017

title

Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver (English)

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Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

24 January 2017

main subject

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GOA release 2020-03-11

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6

Nancy C. Andrews

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24 January 2017

Hiromi Gunshin

1

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24 January 2017

Yuko Fujiwara

2

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24 January 2017

Angel O. Custodio

3

1 reference

24 January 2017

Cristina Direnzo

4

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24 January 2017

Sylvie Robine

5

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24 January 2017

language of work or name

English

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publication date

1 May 2005

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Journal of Clinical Investigation

24 January 2017

published in

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24 January 2017

volume

115

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24 January 2017

issue

5

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24 January 2017

page(s)

1258–1266

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Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload

24 January 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

An iron delivery pathway mediated by a lipocalin

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Identification and localization of divalent metal transporter-1 (DMT-1) in term human placenta

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

The C282Y mutation causing hereditary hemochromatosis does not produce a null allele

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Transferrin receptor is necessary for development of erythrocytes and the nervous system

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Mechanisms of cellular iron acquisition: another iron in the fire

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Genes that modify the hemochromatosis phenotype in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Characterization of transferrin-independent iron transport in K562 cells. Unique properties provide evidence for multiple pathways of iron uptake.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Extracellular ferrireductase activity of K562 cells is coupled to transferrin-independent iron transport

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Molecular and cellular mechanisms underlying iron transport deficiency in microcytic anemia

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Transferrin receptor 1 is differentially required in lymphocyte development.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

The mammalian transferrin-independent iron transport system may involve a surface ferrireductase activity

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1077176

Characterization and genetic studies of microcytic anemia in house mouse

27 November 2018

1 reference

12 December 2020

Low viability, skin lesions, and reduced fertility associated with microcytic anemia in the mouse

1 reference

12 December 2020

Simplified typing of mouse hemoglobin (Hbb) phenotypes using cystamine

1 reference

12 December 2020

An intestinal receptor for heme: Its partial characterization

1 reference

12 December 2020

Characterization of a transferrin-independent uptake system for iron in HeLa cells

1 reference

12 December 2020

Regulation of the transferrin-independent iron transport system in cultured cells

1 reference

12 December 2020

Uptake of non-transferrin-bound iron by both reductive and nonreductive processes is modulated by intracellular iron

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12 December 2020

Iron homeostasis: insights from genetics and animal models

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12 December 2020

Cellular localization of divalent metal transporter DMT-1 in rat kidney

1 reference

12 December 2020

Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice

1 reference

12 December 2020

The G185R mutation disrupts function of the iron transporter Nramp2

1 reference

12 December 2020

Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI24356

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