Disruption of the Bcl6 gene results in an impaired germinal center formation (Q28509600)

GOA release 2020-03-11

author name string

T. Fukuda

1

1 reference

24 January 2017

T. Yoshida

2

1 reference

24 January 2017

S. Okada

3

1 reference

24 January 2017

M. Hatano

4

1 reference

24 January 2017

T. Miki

5

1 reference

24 January 2017

K. Ishibashi

6

1 reference

24 January 2017

S. Okabe

7

1 reference

24 January 2017

H. Koseki

8

1 reference

24 January 2017

S. Hirosawa

9

1 reference

24 January 2017

M. Taniguchi

10

1 reference

24 January 2017

N. Miyasaka

11

1 reference

24 January 2017

T. Tokuhisa

Journal of Experimental Medicine

12

1 reference

24 January 2017

language of work or name

English

0 references

publication date

4 August 1997

1 reference

24 January 2017

1 reference

24 January 2017

186

1 reference

24 January 2017

3

1 reference

24 January 2017

439–448

1 reference

24 January 2017

A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen

1 reference

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Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

19 March 2017

1 reference

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Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas

19 March 2017

1 reference

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The POZ domain: a conserved protein-protein interaction motif

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

BCL-6 protein is expressed in germinal-center B cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

RAG-1-deficient mice have no mature B and T lymphocytes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Mutant mice without B lymphocyte follicles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Antibody response to a T-dependent antigen requires B cell expression of complement receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Transcriptional repression by the proto-oncogene BCL-6.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

In situ studies of the germinal center reaction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Mechanism and regulation of immunoglobulin isotype switching.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Krüppel-like zinc-finger protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Analysis of somatic mutation in five B cell subsets of human tonsil

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Recognition DNA sequence of a novel putative transcription factor, BCL6.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

BCL6 encodes a sequence-specific DNA-binding protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Intraclonal generation of antibody mutants in germinal centres

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

The path of memory B-cell development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Among naive precursor cell subpopulations only progenitors of memory B cells originate germinal centers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

The BCL6 gene is predominantly expressed in keratinocytes at their terminal differentiation stage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Molecular cloning of the breakpoint for 3q27 translocation in B-cell lymphomas and leukemias.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Antigen-induced B-cell death and elimination during germinal-centre immune responses

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones?

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Maturation of the immune response in germinal centers

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

IgG response is impaired in H2-c-fos transgenic mice

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

Germinal centers develop oligoclonally

20 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.186.3.439

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.186.3.439

Generation of memory B cells and plasma cells in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.186.3.439

Locus-specific somatic hypermutation in germinal centre T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.186.3.439

Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.186.3.439

BCL-6 expression during B-cell activation.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

CD28 is required for germinal center formation.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199007

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

27 November 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.186.3.439

Mice deficient for the CD40 ligand

21 January 2018

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12 December 2020

Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers

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12 December 2020

Alternative pathways for the selection of antigen-specific peripheral T cells

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12 December 2020

Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells

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12 December 2020

AN AUTORADIOGRAPHIC STUDY OF THE GERMINAL CENTER IN SPLEEN WHITE PULP DURING EARLY INTERVALS OF THE IMMUNE RESPONSE

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12 December 2020

Distinct pathways of B cell differentiation. I. Residual T cells in athymic mice support the development of splenic germinal centers and B cell memory without an induction of antibody

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12 December 2020

Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma

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12 December 2020

Identifiers

DOI

10.1084/JEM.186.3.439

1 reference

988447

988447

1 reference

1 reference

1 reference