ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth (Q28509641)

24 January 2017

title

ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth (English)

1 reference

Transformation related protein 53 binding protein 2

24 January 2017

0 references

1 reference

Transformation related protein 53

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Virginie Vives

1

1 reference

24 January 2017

Jian Su

2

1 reference

24 January 2017

Shan Zhong

3

1 reference

24 January 2017

Indrika Ratnayaka

4

1 reference

24 January 2017

Elizabeth Slee

5

1 reference

24 January 2017

Robert Goldin

6

1 reference

24 January 2017

Xin Lu

7

1 reference

24 January 2017

publication date

15 May 2006

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24 January 2017

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24 January 2017

volume

20

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24 January 2017

issue

10

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24 January 2017

page(s)

1262–1267

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Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53

24 January 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

ASPP1 and ASPP2: common activators of p53 family members

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

ASPP2 inhibits APP‐BP1‐mediated NEDD8 conjugation to cullin‐1 and decreases APP‐BP1‐induced cell proliferation and neuronal apoptosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

ASPP proteins specifically stimulate the apoptotic function of p53

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

Two cellular proteins that bind to wild-type but not mutant p53

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way.

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

The ASPP family: deciding between life and death after DNA damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

Abnormal mRNA expression of ASPP members in leukemia cell lines.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

Apoptosis stimulating protein of p53 (ASPP2) expression differs in diffuse large B-cell and follicular center lymphoma: correlation with clinical outcome

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

A role for thrombin receptor signaling in endothelial cells during embryonic development

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472901

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/16702401

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/GAD.374006

1 reference

1 reference

1 reference

1 reference