P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis (Q28510364)

Purinergic receptor P2X, ligand-gated ion channel, 7

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Nattapon Panupinthu

1

1 reference

25 January 2017

Joseph T. Rogers

2

1 reference

25 January 2017

Lin Zhao

3

1 reference

25 January 2017

Luis Pastor Solano-Flores

4

1 reference

25 January 2017

Fred Possmayer

5

1 reference

25 January 2017

Stephen M. Sims

6

1 reference

25 January 2017

S. Jeffrey Dixon

P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid

7

1 reference

25 January 2017

language of work or name

English

0 references

publication date

2 June 2008

1 reference

25 January 2017

Journal of Cell Biology

1 reference

25 January 2017

181

1 reference

25 January 2017

859–871

1 reference

25 January 2017

5

1 reference

25 January 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor

19 March 2017

1 reference

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P2X receptors as cell-surface ATP sensors in health and disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies

19 March 2017

1 reference

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The P2X7 nucleotide receptor mediates skeletal mechanotransduction

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

The emerging role of lysophosphatidic acid in cancer

19 March 2017

1 reference

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Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption

19 March 2017

1 reference

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Molecular physiology of P2X receptors

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: a novel role for the P2Y2 receptor in bone remodeling

19 March 2017

1 reference

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The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation

19 March 2017

1 reference

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Altered cytokine production in mice lacking P2X(7) receptors

19 March 2017

1 reference

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Tissue distribution of the P2X7 receptor

19 March 2017

1 reference

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Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

19 March 2017

1 reference

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Physiology and pathophysiology of purinergic neurotransmission

19 March 2017

1 reference

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Mechanical force-induced midpalatal suture remodeling in mice

29 September 2017

1 reference

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Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Biomechanical and molecular regulation of bone remodeling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors

29 September 2017

1 reference

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Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Lysophospholipid G protein-coupled receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Extracellular ATP stimulates the early growth response protein 1 (Egr-1) via a protein kinase C-dependent pathway in the human osteoblastic HOBIT cell line

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation

29 September 2017

1 reference

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Mechanically induced ATP release from human osteoblastic cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

From Wolff's law to the Utah paradigm: insights about bone physiology and its clinical applications

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Lysophosphatidic acid is an osteoblast mitogen whose proliferative actions involve G(i) proteins and protein kinase C, but not P42/44 mitogen-activated protein kinases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Cbfa1 is a positive regulatory factor in chondrocyte maturation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Mammalian phospholipase D structure and regulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Lysophosphatidic acid induces chemotaxis in MC3T3-E1 osteoblastic cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Activation of P2 nucleotide receptors stimulates acid efflux from astrocytes

2 June 2018

1 reference

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ATP and adenosine act as a mitogen for osteoblast-like cells (MC3T3-E1).

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Extracellular nucleotides block bone mineralization in vitro: evidence for dual inhibitory mechanisms involving both P2Y2 receptors and pyrophosphate

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

ATP release mediates fluid flow-induced proliferation of human bone marrow stromal cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Age-dependent properties and quasi-static strain in the rat sagittal suture.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Release and interconversion of P2 receptor agonists by human osteoblast-like cells

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Activity-dependent development of P2X7 current and Ca2+ entry in rabbit osteoclasts

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Bioenergetics and mitochondrial transmembrane potential during differentiation of cultured osteoblasts.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

ATP activates DNA synthesis by acting on P2X receptors in human osteoblast-like MG-63 cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396816

Increased Proliferation Rate of Lymphoid Cells Transfected with the P2X7ATP Receptor

27 November 2018

1 reference

12 December 2020

Expression of P2 receptors in bone and cultured bone cells

1 reference

12 December 2020

Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats

1 reference

12 December 2020

Determination of numbers of osteoprogenitors present in isolated fetal rat calvaria cells in vitro

1 reference

12 December 2020

Stimulation of bone nodule formation in vitro by prostaglandins E1 and E2

1 reference

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Upregulation of P2Y2 nucleotide receptors in rat salivary gland cells during short-term culture

1 reference

12 December 2020

Identifiers

DOI

10.1083/JCB.200708037

1 reference

3680283

3680283

1 reference

1 reference

1 reference