Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities (Q28510453)

GOA release 2020-03-11

R. S. Devon

1

R S

Devon

1 reference

25 January 2017

P. C. Orban

2

P C

Orban

1 reference

25 January 2017

K. Gerrow

3

K

Gerrow

1 reference

25 January 2017

M. A. Barbieri

4

M A

Barbieri

1 reference

25 January 2017

C. Schwab

5

C

Schwab

1 reference

25 January 2017

L. P. Cao

6

L P

Cao

1 reference

25 January 2017

J. R. Helm

7

J R

Helm

1 reference

25 January 2017

N. Bissada

8

N

Bissada

1 reference

25 January 2017

R. Cruz-Aguado

9

R

Cruz-Aguado

1 reference

25 January 2017

T.-L. Davidson

10

T-L

Davidson

1 reference

25 January 2017

J. Witmer

11

J

Witmer

1 reference

25 January 2017

M. Metzler

12

M

Metzler

1 reference

25 January 2017

C. K. Lam

13

C K

Lam

1 reference

25 January 2017

W. Tetzlaff

14

W

Tetzlaff

1 reference

25 January 2017

E. M. Simpson

15

E M

Simpson

1 reference

25 January 2017

J. M. McCaffery

16

J M

McCaffery

1 reference

25 January 2017

A. E. El-Husseini

17

A E

El-Husseini

1 reference

25 January 2017

B. R. Leavitt

18

B R

Leavitt

1 reference

25 January 2017

M. R. Hayden

19

M R

Proceedings of the National Academy of Sciences of the United States of America

Hayden

1 reference

25 January 2017

language of work or name

English

0 references

publication date

20 June 2006

1 reference

25 January 2017

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25 January 2017

103

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25 January 2017

25

1 reference

25 January 2017

9595–9600

1 reference

25 January 2017

describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1480452/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

The first ALS2 missense mutation associated with JPLS reveals new aspects of alsin biological function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

Rab proteins as membrane organizers

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

Rab conversion as a mechanism of progression from early to late endosomes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

rab5 controls early endosome fusion in vitro

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

Long-distance retrograde neurotrophic signaling.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

Not just a sink: endosomes in control of signal transduction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

Reduction of axonal caliber does not alleviate motor neuron disease caused by mutant superoxide dismutase 1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

Rab5 regulates motility of early endosomes on microtubules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

Localization of GTPases by indirect immunofluorescence and immunoelectron microscopy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

Clinicopathological features of primary lateral sclerosis are different from amyotrophic lateral sclerosis.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

AnALS2gene mutation causes hereditary spastic paraplegia in a Pakistani kindred

2 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510197103

Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510197103

A novel role for Rab5-GDI in ligand sequestration into clathrin-coated pits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510197103

Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510197103

NMDA receptor-dependent activation of the small GTPase Rab5 drives the removal of synaptic AMPA receptors during hippocampal LTD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510197103

Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510197103

Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510197103

Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510197103

Mitochondrial Ca2+ buffering in hypoglossal motoneurons from mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510197103

Rab5, an early acting endosomal GTPase, supports in vitro endosome fusion without GTP hydrolysis.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480452

Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of Amyotrophic Lateral Sclerosis

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16769894

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0510197103

1 reference

3544473

ADS bibcode

2006PNAS..103.9595D

0 references

3544473

1 reference

1 reference

1 reference