Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice (Q28511460)

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12 May 2020

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GOA release 2020-03-11

author name string

A Reiner

1

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12 May 2020

N Del Mar

2

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12 May 2020

C A Meade

3

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12 May 2020

H Yang

4

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I Dragatsis

5

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S Zeitlin

6

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D Goldowitz

7

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language of work or name

English

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publication date

1 October 2001

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25 January 2017

Journal of Neuroscience

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25 January 2017

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12 May 2020

volume

21

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25 January 2017

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issue

19

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25 January 2017

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12 May 2020

page(s)

7608-7619

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Huntingtin localization in brains of normal and Huntington's disease patients

12 May 2020

cites work

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Evidence for the preferential localization of glutamate receptor-1 subunits of AMPA receptors to the dendritic spines of medium spiny neurons in rat striatum.

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The identification of a functional nuclear localization signal in the Huntington disease protein

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Homozygote for Huntington disease

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Differential loss of striatal projection neurons in Huntington disease

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A simple and sensitive antigen retrieval method for free-floating and slide-mounted tissue sections

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

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Homozygotes for Huntington's disease

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12 December 2020

Distribution of inclusions in neuronal nuclei and dystrophic neurites in Huntington disease brain

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12 December 2020

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

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12 December 2020

Expression of normal and mutant huntingtin in the developing brain

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12 December 2020

Extensive co-occurrence of substance P and dynorphin in striatal projection neurons: An evolutionarily conserved feature of basal ganglia organization

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Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease

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12 December 2020

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

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12 December 2020

Striatal interneurones: chemical, physiological and morphological characterization

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Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial?

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Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats

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12 December 2020

Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

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12 December 2020

Wild-type huntingtin protects from apoptosis upstream of caspase-3.

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Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease

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12 December 2020

Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration

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Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

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Distribution of vasoactive intestinal polypeptide in the rat and mouse brain

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A molecular investigation of true dominance in Huntington's disease

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Light and electron microscopic immunohistochemical study of dopaminergic terminals in the striatal portion of the pigeon basal ganglia using antisera against tyrosine hydroxylase and dopamine

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Granule cells and cerebellar boundaries: analysis of Unc5h3 mutant chimeras

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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Huntington's disease gene (IT15) is widely expressed in human and rat tissues

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12 December 2020

Genetics and molecular biology of Huntington's disease

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12 December 2020

Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease

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12 December 2020

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

1 reference

12 December 2020

Striatal and nigral neuron subpopulations in rigid Huntington's disease: implications for the functional anatomy of chorea and rigidity-akinesia

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12 December 2020

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

12 December 2020

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

1 reference

12 December 2020

Memory failure in Huntington's disease

1 reference

12 December 2020

Relative survival of striatal projection neurons and interneurons after intrastriatal injection of quinolinic acid in rats

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12 December 2020

Restrictive clonal allocation in the chimeric mouse brain

1 reference

12 December 2020

Trinucleotide instability: a repeating theme in human inherited disorders

1 reference

12 December 2020

Widespread expression of Huntington's disease gene (IT15) protein product

1 reference

12 December 2020

Cellular localization of huntingtin in striatal and cortical neurons in rats: lack of correlation with neuronal vulnerability in Huntington's disease.

1 reference

12 December 2020

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

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12 December 2020

Partial characterisation of murine huntingtin and apparent variations in the subcellular localisation of huntingtin in human, mouse and rat brain.

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12 December 2020

Electrophysiological characteristics of immunochemically identified rat oxytocin and vasopressin neurones in vitro.

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12 December 2020

Differential expression of normal and mutant Huntington's disease gene alleles

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12 December 2020

Reduced expression of preproenkephalin in striatal neurons from Huntington's disease patients

1 reference

12 December 2020

Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat

1 reference

12 December 2020

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

1 reference

12 December 2020

Calbindin D28K as a marker for the degeneration of the striatonigral pathway in Huntington's disease

1 reference

12 December 2020

Inactivation of the mouse Huntington's disease gene homolog Hdh

1 reference

12 December 2020

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

1 reference

12 December 2020

The patterns of neurotransmitter and neuropeptide co-occurrence among striatal projection neurons: conclusions based on recent findings

1 reference

12 December 2020

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

1 reference

12 December 2020

Relative resistance of striatal neurons containing calbindin or parvalbumin to quinolinic acid-mediated excitotoxicity compared to other striatal neuron types.

1 reference

12 December 2020

Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues.

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12 December 2020

The fatal attraction of polyglutamine-containing proteins.

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12 December 2020

Neuropathological classification of Huntington's disease

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12 December 2020

A Comparison of Neurotransmitter-Specific and Neuropeptide-Specific Neuronal Cell Types Present in the Dorsal Cortex in Turtles with Those Present in the Isocortex in Mammals: Implications for the Evolution of Isocortex; pp. 53–72

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Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice

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12 December 2020

Morphometric demonstration of atrophic changes in the cerebral cortex, white matter, and neostriatum in Huntington's disease

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12 December 2020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

12 December 2020

Life without huntingtin: normal differentiation into functional neurons

1 reference

12 December 2020

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

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12 December 2020

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

1 reference

12 December 2020

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

12 December 2020

Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysis

1 reference

12 December 2020

Loss of normal huntingtin function: new developments in Huntington's disease research

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12 December 2020

Huntington's disease gene: regional and cellular expression in brain of normal and affected individuals

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12 December 2020

Immunohistochemical localization of DARPP-32 in striatal projection neurons and striatal interneurons: implications for the localization of D1-like dopamine receptors on different types of striatal neurons

1 reference

12 December 2020

The cortical lesion of Huntington's disease: further neurochemical characterization, and reproduction of some of the histological and neurochemical features by N-methyl-D-aspartate lesions of rat cortex

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12 December 2020

Neuronal intranuclear inclusions in polyglutamine diseases: nuclear weapons or nuclear fallout?

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12 December 2020

Evidence for a recruitment and sequestration mechanism in Huntington's disease

1 reference

12 December 2020

10.1523/JNEUROSCI.21-19-07608.2001

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762912&resulttype=core&format=json

12 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762912&resulttype=core&format=json

12 May 2020

2 references

25 January 2017