Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release (Q28511933)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0061987

negative regulation of transcription by glucose

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Gene Ontology release 2020-05-02

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GOA release 2020-03-11

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Haiyan Wang

1

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25 January 2017

Benoit R. Gauthier

2

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25 January 2017

Kerstin A. Hagenfeldt-Johansson

3

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25 January 2017

Mariella Iezzi

4

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25 January 2017

Claes B. Wollheim

Journal of Biological Chemistry

5

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25 January 2017

language of work or name

English

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publication date

17 May 2002

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25 January 2017

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25 January 2017

277

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25 January 2017

20

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25 January 2017

17564–17570

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25 January 2017

Regulation of a transcription factor network required for differentiation and metabolism.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte-specific genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Overproduction of a truncated hepatocyte nuclear factor 3 protein inhibits expression of liver-specific genes in hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

The molecular physiology of hepatic nuclear factor 3 in the regulation of gluconeogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

The hepatocyte nuclear factor 3 (HNF3 or FOXA) family in metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Hepatocyte-nuclear factor 3 beta gene transcripts generate protein isoforms with different transactivation properties on the glucagon gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Familial hyperinsulinism caused by an activating glucokinase mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Mutations in the sulonylurea receptor gene are associated with familial hyperinsulinism in Ashkenazi Jews.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Loss of functional KATP channels in pancreatic beta-cells causes persistent hyperinsulinemic hypoglycemia of infancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Transcriptional activation by tetracyclines in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Signaling in channel/enzyme multimers: ATPase transitions in SUR module gate ATP-sensitive K+ conductance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Adenovirus-mediated increase in HNF-3beta or HNF-3alpha shows differences in levels of liver glycogen and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome: predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene. HI/HA Contributing Investigators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

Genetic variation in the hepatocyte nuclear factor-3beta gene (HNF3B) does not contribute to maturity-onset diabetes of the young in French Caucasians

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200

The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111037200