PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma (Q28533981)

1

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Katherine Misuraca

2

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Francisco Cordero

3

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Elena Dobrikova

4

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Hooney D Min

5

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Matthias Gromeier

6

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Oren J Becher

Creative Commons Attribution 4.0 International

8

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language of work or name

English

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publication date

2013

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published in

PLOS One

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volume

8

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issue

10

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page(s)

e77639

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copyright license

start time

2 October 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma

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The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

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p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells

29 September 2017

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Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy

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An experimental xenograft mouse model of diffuse pontine glioma designed for therapeutic testing

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Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma

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Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expression

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Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM

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Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease

29 September 2017

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Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma

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Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

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Phase I, dose-escalation trial of the oral cyclin-dependent kinase 4/6 inhibitor PD 0332991, administered using a 21-day schedule in patients with advanced cancer

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Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets.

2 June 2018

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Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0077639